Aminoguanidine hydrochloride

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Cat.No. 0787 - Aminoguanidine hydrochloride | CH6N4.HCl | CAS No. 1937-19-5
Description: Irreversible iNOS inhibitor
Citations (1)

Biological Activity

Irreversible inhibitor of iNOS that displays some selectivity over eNOS and nNOS. Exhibits antioxidant and radioprotective effects in vivo.

Technical Data

M. Wt 110.55
Formula CH6N4.HCl
Storage Store at RT
CAS Number 1937-19-5
PubChem ID 16017
Smiles Cl.N=C(NN)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in water

Preparing Stock Solutions

The following data is based on the product molecular weight 110.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 9.05 mL 45.23 mL 90.46 mL
5 mM 1.81 mL 9.05 mL 18.09 mL
10 mM 0.9 mL 4.52 mL 9.05 mL
50 mM 0.18 mL 0.9 mL 1.81 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Griffiths et al (1993) Aminoguanidine selectively inhibits inducible nitric oxide synthase. Br.J.Pharmacol. 110 963 PMID: 7507781

Huang et al (2009) Aminoguanidine alleviates radiation-induced small-bowel damage through its antioxidant effect. Int.J.Radiat.Oncol.Biol.Phys. 74 237 PMID: 19362242

Laszlo et al (1995) Aminoguanidine inhibits both constitutive and inducible nitric oxide synthase isoforms in rat intestinal microvasculature in vivo. Eur.J.Pharmacol. 272 169 PMID: 7536162

Moore and Handy (1997) Selective inhibitors of neuronal nitric oxide synthase - is no NOS really good NOS for the nervous system? TiPS 18 204 PMID: 9226999

If you know of a relevant reference for Aminoguanidine hydrochloride, please let us know.

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Keywords: Aminoguanidine hydrochloride, supplier, Irreversible, iNOS, inhibitors, inhibits, Nitric, Oxide, Signaling, Signalling, Inducible, NO, Synthases, iNOS, iNOS, Tocris Bioscience

1 Citation for Aminoguanidine hydrochloride

Citations are publications that use Tocris products. Selected citations for Aminoguanidine hydrochloride include:

Jakubowska et al (2016) Nitric oxide signals are interlinked with calcium signals in normal pancreatic stellate cells upon oxidative stress and inflammation. Open Biol. 6 160149 PMID: 27488376

Do you know of a great paper that uses Aminoguanidine hydrochloride from Tocris? If so please let us know.

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