Irreversible inhibitor of iNOS that displays some selectivity over eNOS and nNOS. Exhibits antioxidant and radioprotective effects in vivo.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 100 mM in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 110.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||9.05 mL||45.23 mL||90.46 mL|
|5 mM||1.81 mL||9.05 mL||18.09 mL|
|10 mM||0.9 mL||4.52 mL||9.05 mL|
|50 mM||0.18 mL||0.9 mL||1.81 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Griffiths et al (1993) Aminoguanidine selectively inhibits inducible nitric oxide synthase. Br.J.Pharmacol. 110 963 PMID: 7507781
Huang et al (2009) Aminoguanidine alleviates radiation-induced small-bowel damage through its antioxidant effect. Int.J.Radiat.Oncol.Biol.Phys. 74 237 PMID: 19362242
Laszlo et al (1995) Aminoguanidine inhibits both constitutive and inducible nitric oxide synthase isoforms in rat intestinal microvasculature in vivo. Eur.J.Pharmacol. 272 169 PMID: 7536162
Moore and Handy (1997) Selective inhibitors of neuronal nitric oxide synthase - is no NOS really good NOS for the nervous system? TiPS 18 204 PMID: 9226999
If you know of a relevant reference for Aminoguanidine hydrochloride, please let us know.
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Keywords: Irreversible iNOS inhibitors inhibits Nitric Oxide Signaling Signalling Inducible NO Synthases iNOS
1 Citation for Aminoguanidine hydrochloride
Citations are publications that use Tocris products. Selected citations for Aminoguanidine hydrochloride include:
Jakubowska et al (2016) Nitric oxide signals are interlinked with calcium signals in normal pancreatic stellate cells upon oxidative stress and inflammation. Open Biol. 6 160149 PMID: 27488376
Do you know of a great paper that uses Aminoguanidine hydrochloride from Tocris? If so please let us know.