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AMI-193 is a selective 5-HT antagonist, which binds to 5-HT2 sites as potently as spiperone but has lower affinity for 5-HT2C receptors. Also a high affinity D2 receptor antagonist (Ki = 3 nM). Lacks the disruptive effect of spiperone on animal behavior.
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The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Czoty et al (2000) Behavioural effects of AMI-193, a 5-HT2A- and DA D2-receptor antagonist, in the squirrel monkey. Pharmacol.Biochem.Behav. 67 257 PMID: 11124389
Ismaiel et al (1993) Antagonism of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane stimulus with a newly identified 5HT2 versus 5HT1C selective antagonist. J.Med.Chem. 36 2519 PMID: 8355253
Keywords: AMI-193, AMI-193 supplier, Selective, 5-HT2, antagonists, D2-like, receptor, Non-Selective, Serotonin, Receptors, Dopamine, dopaminergic, spiramide, Spiramide, Non-selective, 0524, Tocris Bioscience
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