Discontinued Product

AMI-193 (Cat. No. 0524) has been withdrawn from sale for commercial reasons.
Description: D2-like antagonist; also selective 5-HT2 antagonist
Alternative Names: Spiramide
Chemical Name: 8-[3-(4-Fluorophenoxy)propyl]-1-phenyl-1,3,8-triazaspiro[4.5]-decanone
Purity: ≥99% (HPLC)
Literature (2)

Biological Activity for AMI-193

AMI-193 is a selective 5-HT antagonist, which binds to 5-HT2 sites as potently as spiperone but has lower affinity for 5-HT2C receptors. Also a high affinity D2 receptor antagonist (Ki = 3 nM). Lacks the disruptive effect of spiperone on animal behavior.

Technical Data for AMI-193

M. Wt 383.46
Formula C22H26FN3O2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 510-74-7
PubChem ID 68186

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for AMI-193

Certificate of Analysis / Product Datasheet
Select another batch:

References for AMI-193

References are publications that support the biological activity of the product.

Czoty et al (2000) Behavioural effects of AMI-193, a 5-HT2A- and DA D2-receptor antagonist, in the squirrel monkey. Pharmacol.Biochem.Behav. 67 257 PMID: 11124389

Ismaiel et al (1993) Antagonism of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane stimulus with a newly identified 5HT2 versus 5HT1C selective antagonist. J.Med.Chem. 36 2519 PMID: 8355253

View Related Products by Product Action

View all Non-selective Dopamine Antagonists

Keywords: AMI-193, AMI-193 supplier, Selective, 5-HT2, antagonists, D2-like, receptor, Non-Selective, Serotonin, Receptors, Dopamine, dopaminergic, spiramide, Spiramide, Non-selective, 0524, Tocris Bioscience

Citations for AMI-193

Citations are publications that use Tocris products.

Currently there are no citations for AMI-193.

Reviews for AMI-193

There are currently no reviews for this product. Be the first to review AMI-193 and earn rewards!

Have you used AMI-193?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Dopamine Receptors Scientific Review

Dopamine Receptors Scientific Review

Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.