AMG 837 hemicalcium salt

Pricing Availability Delivery Time Qty
Cat.No. 6082 - AMG 837 hemicalcium salt | C26H20F3O3.½Ca | CAS No. 1291087-14-3
Description: Potent free fatty acid receptor 1 (FFA1/GPR40) partial agonist
Chemical Name: (βS)-β-1-Propyn-1-yl-4-[[4'-(trifluoromethyl)[1,1'-biphenyl]-3-yl]methoxy]benzenepropanoic acid hemicalcium salt
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent free fatty acid receptor 1 (FFA1/GPR40) partial agonist (EC50 values are 13.5, 22.6 and 31.7 nM at human, mouse and rat receptors, respectively). Interacts allosterically with full FFA1 agonist Docosahexaenoic acid (Cat. No. 3687). Potentiates glucose-dependent stimulation of insulin in vivo. Antidiabetic.

Technical Data

M. Wt 457.47
Formula C26H20F3O3.½Ca
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1291087-14-3
PubChem ID 46854655
InChI Key WCZAHGONZBHQSA-UHFFFAOYSA-L
Smiles CC#C[C@H](C1=CC=C(C=C1)OCC2=CC=CC(C3=CC=C(C(F)(F)F)C=C3)=C2)CC([O-])=O.CC#C[C@H](C4=CC=C(C=C4)OCC5=CC=CC(C6=CC=C(C(F)(F)F)C=C6)=C5)CC([O-])=O.[Ca+2]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 45.75 100

Preparing Stock Solutions

The following data is based on the product molecular weight 457.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.19 mL 10.93 mL 21.86 mL
5 mM 0.44 mL 2.19 mL 4.37 mL
10 mM 0.22 mL 1.09 mL 2.19 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Houze et al (2012) AMG 837: a potent, orally bioavailable GPR40 agonist. Bioorg.Med.Chem.Lett. 22 1267 PMID: 22217876

Lin et al (2012) Identification and pharmacological characterization of multiple allosteric binding sites on the free fatty acid 1 receptor. Mol.Pharmacol. 82 843 PMID: 22859723

Lin et al (2011) AMG 837: a novel GPR40/FFA1 agonist that enhances insulin secretion and lowers glucose levels in rodents. PLoS One 6 e27270 PMID: 22087278


If you know of a relevant reference for AMG 837 hemicalcium salt, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Free Fatty Acid Receptor Agonists

Keywords: AMG 837 hemicalcium salt, AMG 837 hemicalcium salt supplier, AMG837, hemicalcium, salt, Potent, free, fatty, acid, receptors, 1, FFA1, GPR40, partial, agonists, allosteric, modulator, antidiabetic, insulin, agonism, type, 2, diabetes, orally, bioavailable, Free, Fatty, Acid, Receptors, 6082, Tocris Bioscience

Citations for AMG 837 hemicalcium salt

Citations are publications that use Tocris products.

Currently there are no citations for AMG 837 hemicalcium salt. Do you know of a great paper that uses AMG 837 hemicalcium salt from Tocris? Please let us know.

Reviews for AMG 837 hemicalcium salt

There are currently no reviews for this product. Be the first to review AMG 837 hemicalcium salt and earn rewards!

Have you used AMG 837 hemicalcium salt?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling