AM 92016 hydrochloride

Discontinued Product

AM 92016 hydrochloride (Cat. No. 0876) has been withdrawn from sale for commercial reasons.
Description: KV channel blocker
Chemical Name: 1-(4-Methanesulfonamidophenoxy)-3-(N-methyl-3,4-dichlorophenylethylamino)-2-propanol hydrochloride
Purity: ≥98% (HPLC)
Reviews (1)
Literature (5)

Biological Activity for AM 92016 hydrochloride

A specific blocker of the time dependent delayed rectifier potassium current, devoid of any β-adrenoceptor blocking activity. Exhibits proarrhythmic and prohypertensive activity in vivo.

Technical Data for AM 92016 hydrochloride

M. Wt 483.84
Formula C19H24Cl2N2O4S.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 133229-11-5
PubChem ID 45073415
Smiles Cl.CN(CCC1=CC(Cl)=C(Cl)C=C1)CC(O)COC1=CC=C(NS(C)(=O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for AM 92016 hydrochloride

Certificate of Analysis / Product Datasheet
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References for AM 92016 hydrochloride

References are publications that support the biological activity of the product.

Conners et al (1992) Actions and mechanisms of action of novel analogues of sot. on guinea-pig and rabbit ventricular cells. Br.J.Pharmacol. 106 958 PMID: 1393293

Hagerty et al (1996) The in vivo cardiovascular effects of a putative class III anti-arrhythmic drug, AM 92016. J.Pharm.Pharmacol. 48 417 PMID: 8794994

Lei and Brown (1998) Inhibition by compound II, a sot. analogue, of delayed rectifier current (iK) in rabbit sino-atrial node cells. Naunyn Schmiedebergs Arch.Pharmacol. 357 260 PMID: 9550297

Palen et al (2005) Role of SHP-1, Kv1.2 and cGMP in nitric oxide-induced ERK1/2 MAP kinase dephosphorylation in rat vascular smooth muscle cells. Cardiovasc.Res. 68 268 PMID: 15967421

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Citations for AM 92016 hydrochloride

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Currently there are no citations for AM 92016 hydrochloride.

Reviews for AM 92016 hydrochloride

Average Rating: 5 (Based on 1 Review.)

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Great Kv blocker that works ideally on cell biology labs.
By Anonymous on 10/15/2018
Assay Type: In Vitro
Species: Mouse

Have used the product for carrying out study on Kv channel regulation by accessory subunits expressed differently on mouse. Found that it works ideally and also is a great stable product on lab conditions. Great buy and would purchase again soon.

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