AM 92016 hydrochloride

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Cat.No. 0876 - AM 92016 hydrochloride | C19H24Cl2N2O4S.HCl | CAS No. 133229-11-5
Description: KV channel blocker
Chemical Name: 1-(4-Methanesulfonamidophenoxy)-3-(N-methyl-3,4-dichlorophenylethylamino)-2-propanol hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

A specific blocker of the time dependent delayed rectifier potassium current, devoid of any β-adrenoceptor blocking activity. Exhibits proarrhythmic and prohypertensive activity in vivo.

Compound Libraries

AM 92016 hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 483.84
Formula C19H24Cl2N2O4S.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 133229-11-5
PubChem ID 45073415
InChI Key TXOARFPCQOBODS-UHFFFAOYSA-N
Smiles Cl.CN(CCC1=CC(Cl)=C(Cl)C=C1)CC(O)COC1=CC=C(NS(C)(=O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 48.38 100
ethanol 48.38 100
water 24.19 50

Preparing Stock Solutions

The following data is based on the product molecular weight 483.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.07 mL 10.33 mL 20.67 mL
5 mM 0.41 mL 2.07 mL 4.13 mL
10 mM 0.21 mL 1.03 mL 2.07 mL
50 mM 0.04 mL 0.21 mL 0.41 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Conners et al (1992) Actions and mechanisms of action of novel analogues of sotalol on guinea-pig and rabbit ventricular cells. Br.J.Pharmacol. 106 958 PMID: 1393293

Hagerty et al (1996) The in vivo cardiovascular effects of a putative class III anti-arrhythmic drug, AM 92016. J.Pharm.Pharmacol. 48 417 PMID: 8794994

Lei and Brown (1998) Inhibition by compound II, a sotalol analogue, of delayed rectifier current (iK) in rabbit sino-atrial node cells. Naunyn Schmiedebergs Arch.Pharmacol. 357 260 PMID: 9550297

Palen et al (2005) Role of SHP-1, Kv1.2 and cGMP in nitric oxide-induced ERK1/2 MAP kinase dephosphorylation in rat vascular smooth muscle cells. Cardiovasc.Res. 68 268 PMID: 15967421


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Citations for AM 92016 hydrochloride

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