AM 2394

Discontinued Product

AM 2394 (Cat. No. 6034) has been withdrawn from sale for commercial reasons.
Description: Potent glucokinase activator; orally bioavailable
Chemical Name: N-[6'-(2-Hydroxy-2-methylpropoxy)-4-[(5-methyl-3-pyridinyl)oxy][3,3'-bipyridin]-6-yl]-N'-methylurea
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity for AM 2394

AM 2394 is a potent glucokinase activator (EC50 = 60 nM). Orally bioavailable. Reduces plasma glucose levels in an oral glucose tolerance test in ob/ob mice.

Technical Data for AM 2394

M. Wt 423.47
Formula C22H25N5O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1442684-77-6
PubChem ID 71603585
Smiles O=C(NC)NC1=CC(OC2=CC(C)=CN=C2)=C(C3=CN=C(OCC(C)(C)O)C=C3)C=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for AM 2394

References are publications that support the biological activity of the product.

Dransfield et al (2016) Novel series of potent glucokinase activators leading to the discovery of AM-2394. ACS Med.Chem.Lett. 7 714 PMID: 27437083

View Related Products by Product Action

View all Hexokinases Activators

Keywords: AM 2394, AM 2394 supplier, AM2394, glucokinase, activators, activates, GKA, antidiabetic, potent, orally, bioavailable, Hexokinases, Enzyme, Substrates, /, Activators, 6034, Tocris Bioscience

Citations for AM 2394

Citations are publications that use Tocris products.

Currently there are no citations for AM 2394.

Reviews for AM 2394

There are currently no reviews for this product. Be the first to review AM 2394 and earn rewards!

Have you used AM 2394?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cancer Metabolism Research Product Guide

Cancer Metabolism Research Product Guide

This product guide reviews some of the main areas in cancer metabolism research and lists around 150 products that can be used to investigate metabolic pathways in cancer including:

Cancer Metabolism Poster

Cancer Metabolism Poster

This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.