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Biological Activity for AM 2394
AM 2394 is a potent glucokinase activator (EC50 = 60 nM). Orally bioavailable. Reduces plasma glucose levels in an oral glucose tolerance test in ob/ob mice.
Technical Data for AM 2394
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for AM 2394
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|ethanol||4.23||10 with gentle warming|
Preparing Stock Solutions for AM 2394
The following data is based on the product molecular weight 423.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.36 mL||11.81 mL||23.61 mL|
|5 mM||0.47 mL||2.36 mL||4.72 mL|
|10 mM||0.24 mL||1.18 mL||2.36 mL|
|50 mM||0.05 mL||0.24 mL||0.47 mL|
References for AM 2394
References are publications that support the biological activity of the product.
Dransfield et al (2016) Novel series of potent glucokinase activators leading to the discovery of AM-2394. ACS Med.Chem.Lett. 7 714 PMID: 27437083
If you know of a relevant reference for AM 2394, please let us know.
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Keywords: AM 2394, AM 2394 supplier, AM2394, glucokinase, activators, activates, GKA, antidiabetic, potent, orally, bioavailable, Hexokinases, Enzyme, Substrates, /, Activators, 6034, Tocris Bioscience
Citations for AM 2394
Citations are publications that use Tocris products.
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Literature in this Area
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