Potent glucokinase activator (EC50 = 60 nM). Orally bioavailable. Reduces plasma glucose levels in an oral glucose tolerance test in ob/ob mice.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|ethanol||4.23||10mM with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 423.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.36 mL||11.81 mL||23.61 mL|
|5 mM||0.47 mL||2.36 mL||4.72 mL|
|10 mM||0.24 mL||1.18 mL||2.36 mL|
|50 mM||0.05 mL||0.24 mL||0.47 mL|
References are publications that support the products' biological activity.
Dransfield et al (2016) Novel series of potent glucokinase activators leading to the discovery of AM-2394. ACS Med.Chem.Lett. 7 714 PMID: 27437083
If you know of a relevant reference for AM 2394, please let us know.
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Keywords: AM 2394, supplier, AM2394, glucokinase, activators, activates, GKA, antidiabetic, potent, orally, bioavailable, Hexokinases, Enzyme, Substrates, /, Activators, Hexokinases, Tocris Bioscience
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