AM 2394

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Cat.No. 6034 - AM 2394 | C22H25N5O4 | CAS No. 1442684-77-6
Description: Potent glucokinase activator; orally bioavailable
Chemical Name: N-[6'-(2-Hydroxy-2-methylpropoxy)-4-[(5-methyl-3-pyridinyl)oxy][3,3'-bipyridin]-6-yl]-N'-methylurea
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity for AM 2394

AM 2394 is a potent glucokinase activator (EC50 = 60 nM). Orally bioavailable. Reduces plasma glucose levels in an oral glucose tolerance test in ob/ob mice.

Technical Data for AM 2394

M. Wt 423.47
Formula C22H25N5O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1442684-77-6
PubChem ID 71603585
Smiles O=C(NC)NC1=CC(OC2=CC(C)=CN=C2)=C(C3=CN=C(OCC(C)(C)O)C=C3)C=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AM 2394

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 42.35 100
ethanol 4.23 10 with gentle warming

Preparing Stock Solutions for AM 2394

The following data is based on the product molecular weight 423.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.36 mL 11.81 mL 23.61 mL
5 mM 0.47 mL 2.36 mL 4.72 mL
10 mM 0.24 mL 1.18 mL 2.36 mL
50 mM 0.05 mL 0.24 mL 0.47 mL

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References for AM 2394

References are publications that support the biological activity of the product.

Dransfield et al (2016) Novel series of potent glucokinase activators leading to the discovery of AM-2394. ACS Med.Chem.Lett. 7 714 PMID: 27437083

If you know of a relevant reference for AM 2394, please let us know.

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Keywords: AM 2394, AM 2394 supplier, AM2394, glucokinase, activators, activates, GKA, antidiabetic, potent, orally, bioavailable, Hexokinases, Enzyme, Substrates, /, Activators, 6034, Tocris Bioscience

Citations for AM 2394

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