AM 2394

Pricing Availability Delivery Time Qty
Cat.No. 6034 - AM 2394 | C22H25N5O4 | CAS No. 1442684-77-6
Description: Potent glucokinase activator; orally bioavailable
Chemical Name: N-[6'-(2-Hydroxy-2-methylpropoxy)-4-[(5-methyl-3-pyridinyl)oxy][3,3'-bipyridin]-6-yl]-N'-methylurea
Purity: ≥98% (HPLC)

Biological Activity

Potent glucokinase activator (EC50 = 60 nM). Orally bioavailable. Reduces plasma glucose levels in an oral glucose tolerance test in ob/ob mice.

Technical Data

M. Wt 423.47
Formula C22H25N5O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1442684-77-6
PubChem ID 71603585
Smiles O=C(NC)NC1=CC(OC2=CC(C)=CN=C2)=C(C3=CN=C(OCC(C)(C)O)C=C3)C=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 42.35 100
ethanol 4.23 10mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 423.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.36 mL 11.81 mL 23.61 mL
5 mM 0.47 mL 2.36 mL 4.72 mL
10 mM 0.24 mL 1.18 mL 2.36 mL
50 mM 0.05 mL 0.24 mL 0.47 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Dransfield et al (2016) Novel series of potent glucokinase activators leading to the discovery of AM-2394. ACS Med.Chem.Lett. 7 714 PMID: 27437083

If you know of a relevant reference for AM 2394, please let us know.

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Keywords: AM 2394, supplier, AM2394, glucokinase, activators, activates, GKA, antidiabetic, potent, orally, bioavailable, Hexokinases, Enzyme, Substrates, /, Activators, Hexokinases, Tocris Bioscience

Citations for AM 2394

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