Alfuzosin hydrochloride

Discontinued Product

Alfuzosin hydrochloride (Cat. No. 3305) has been withdrawn from sale for commercial reasons.
Description: Uroselective α1 antagonist
Chemical Name: N-[3-[(4-Amino-6,7-dimethoxy-2-quinazolinyl)methylamino]propyl]tetrahydro-2-furancarboxamide hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews (1)
Literature (1)

Biological Activity for Alfuzosin hydrochloride

Alfuzosin hydrochloride is a functionally uro-selective α1 adrenoceptor antagonist that does not discriminate between α1 subtypes. Inhibits increases in intraurethral pressure caused by phenylephrine-induced contraction by 81% with minor cardiovascular effects. Also relaxes corpus cavernosum tissue (pIC50 = 7.64) in vitro.

Technical Data for Alfuzosin hydrochloride

M. Wt 425.91
Formula C19H27N5O4.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 81403-68-1
PubChem ID 71764
InChI Key YTNKWDJILNVLGX-UHFFFAOYSA-N
Smiles NC2=NC(N(C)CCCNC(C3CCCO3)=O)=NC1=CC(OC)=C(OC)C=C12.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Alfuzosin hydrochloride

References for Alfuzosin hydrochloride

References are publications that support the biological activity of the product.

Palea and Barras (2003) Comparison of the relaxant effects of alfuzosin, phentol. and silde. on rabbit isolated corpus cavernosum. BJU Int. 91 873 PMID: 12780851

Lee (2003) Alfuzosin hydrocholride for the treatment of benign prostatic hyperplasia. Am.J.Health Syst.Pharm. 60 1426 PMID: 12892027

Yamaguchi et al (2005) Effects of different alpha-1 adrenoceptor blockers on proximal urethral function using in vivo isovolumetric pressure changes. J.Smooth Muscle Res. 41 247 PMID: 16428864

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Keywords: Alfuzosin hydrochloride, Alfuzosin hydrochloride supplier, Uroselective, α1-adrenoceptor, alpha1-adrenoceptor, a1-adrenoceptor, a1-adrenergic, antagonists, α1-adrenergic, alpha1-adrenergic, Receptors, Adrenergic, Alpha-1, 3305, Tocris Bioscience

Citations for Alfuzosin hydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for Alfuzosin hydrochloride.

Reviews for Alfuzosin hydrochloride

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Used to investigate cell metabolism.
By Anonymous on 02/27/2023
Assay Type: In Vitro
Species: Rat
Cell Line/Tissue: Primary hippocampal neurons

The drug was incubated at 10 μM to investigate a potential effect on cell metabolism.


Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.