Alfuzosin hydrochloride

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Cat.No. 3305 - Alfuzosin hydrochloride | C19H27N5O4.HCl | CAS No. 81403-68-1
Description: Uroselective α1 antagonist
Chemical Name: N-[3-[(4-Amino-6,7-dimethoxy-2-quinazolinyl)methylamino]propyl]tetrahydro-2-furancarboxamide hydrochloride
Purity: ≥99% (HPLC)
Literature (4)

Biological Activity

Functionally uro-selective α1 adrenoceptor antagonist that does not discriminate between α1 subtypes. Inhibits increases in intraurethral pressure caused by phenylephrine-induced contraction by 81% with minor cardiovascular effects. Also relaxes corpus cavernosum tissue (pIC50 = 7.64) in vitro.

Technical Data

M. Wt 425.91
Formula C19H27N5O4.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 81403-68-1
PubChem ID 71764
Smiles NC2=NC(N(C)CCCNC(C3CCCO3)=O)=NC1=CC(OC)=C(OC)C=C12.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 10.65 25
DMSO 10.65 25

Preparing Stock Solutions

The following data is based on the product molecular weight 425.91. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 9.39 mL 46.96 mL 93.92 mL
1.25 mM 1.88 mL 9.39 mL 18.78 mL
2.5 mM 0.94 mL 4.7 mL 9.39 mL
12.5 mM 0.19 mL 0.94 mL 1.88 mL

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References are publications that support the biological activity of the product.

Palea and Barras (2003) Comparison of the relaxant effects of alfuzosin, phentol. and silde. on rabbit isolated corpus cavernosum. BJU Int. 91 873 PMID: 12780851

Lee (2003) Alfuzosin hydrocholride for the treatment of benign prostatic hyperplasia. Am.J.Health Syst.Pharm. 60 1426 PMID: 12892027

Yamaguchi et al (2005) Effects of different alpha-1 adrenoceptor blockers on proximal urethral function using in vivo isovolumetric pressure changes. J.Smooth Muscle Res. 41 247 PMID: 16428864

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