Alfuzosin hydrochloride

Discontinued Product

Alfuzosin hydrochloride (Cat. No. 3305) has been withdrawn from sale for commercial reasons.
Cat.No. 3305 - Alfuzosin hydrochloride | C19H27N5O4.HCl | CAS No. 81403-68-1
Description: Uroselective α1 antagonist
Chemical Name: N-[3-[(4-Amino-6,7-dimethoxy-2-quinazolinyl)methylamino]propyl]tetrahydro-2-furancarboxamide hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (4)

Biological Activity for Alfuzosin hydrochloride

Alfuzosin hydrochloride is a functionally uro-selective α1 adrenoceptor antagonist that does not discriminate between α1 subtypes. Inhibits increases in intraurethral pressure caused by phenylephrine-induced contraction by 81% with minor cardiovascular effects. Also relaxes corpus cavernosum tissue (pIC50 = 7.64) in vitro.

Technical Data for Alfuzosin hydrochloride

M. Wt 425.91
Formula C19H27N5O4.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 81403-68-1
PubChem ID 71764
InChI Key YTNKWDJILNVLGX-UHFFFAOYSA-N
Smiles NC2=NC(N(C)CCCNC(C3CCCO3)=O)=NC1=CC(OC)=C(OC)C=C12.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Alfuzosin hydrochloride

References for Alfuzosin hydrochloride

References are publications that support the biological activity of the product.

Palea and Barras (2003) Comparison of the relaxant effects of alfuzosin, phentol. and silde. on rabbit isolated corpus cavernosum. BJU Int. 91 873 PMID: 12780851

Lee (2003) Alfuzosin hydrocholride for the treatment of benign prostatic hyperplasia. Am.J.Health Syst.Pharm. 60 1426 PMID: 12892027

Yamaguchi et al (2005) Effects of different alpha-1 adrenoceptor blockers on proximal urethral function using in vivo isovolumetric pressure changes. J.Smooth Muscle Res. 41 247 PMID: 16428864

View Related Products by Target

View Related Products by Product Action

View all Adrenergic α1 Receptor Antagonists

Keywords: Alfuzosin hydrochloride, Alfuzosin hydrochloride supplier, Uroselective, α1-adrenoceptor, alpha1-adrenoceptor, a1-adrenoceptor, a1-adrenergic, antagonists, α1-adrenergic, alpha1-adrenergic, Receptors, Adrenergic, Alpha-1, 3305, Tocris Bioscience

Citations for Alfuzosin hydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for Alfuzosin hydrochloride.

Reviews for Alfuzosin hydrochloride

There are currently no reviews for this product. Be the first to review Alfuzosin hydrochloride and earn rewards!

Have you used Alfuzosin hydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
GPCR Product Listing

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Cardiovascular Poster

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.

Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.