Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewAlantolactone
Description: Antiproliferative; induces activin/Smad3 signaling
Chemical Name: (3aR,5S,8aR,9aR)-3a,5,6,7,8,8a,9,9a-Octahydro-5,8a-dimethyl-3-methylenenaphtho[2,3-b]furan-2(3H)-one
Purity: ≥98% (HPLC)
Biological Activity for Alantolactone
Alantolactone is a sesquiterpene lactone. Induces activin/SMAD3 signaling and disrupts Cripto-1/activin receptor type II A interaction. Displays antiproliferative activity in human colon adenocarcinoma HCT-8 cells.
Technical Data for Alantolactone
| M. Wt | 232.32 |
| Formula | C15H20O2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 546-43-0 |
| PubChem ID | 72724 |
| InChI Key | PXOYOCNNSUAQNS-AGNJHWRGSA-N |
| Smiles | O=C3C([C@@]2([H])C=C1[C@@H](C)CCC[C@@](C)1C[C@]([H])2O3)=C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Alantolactone
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 23.23 | 100 | |
| ethanol | 23.23 | 100 |
Preparing Stock Solutions for Alantolactone
The following data is based on the product molecular weight 232.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.3 mL | 21.52 mL | 43.04 mL |
| 5 mM | 0.86 mL | 4.3 mL | 8.61 mL |
| 10 mM | 0.43 mL | 2.15 mL | 4.3 mL |
| 50 mM | 0.09 mL | 0.43 mL | 0.86 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for Alantolactone
References for Alantolactone
References are publications that support the biological activity of the product.
Dupuis & Brisson et al (1976) Toxic effect of alantolactone and dihydroalantolactone in in vitro cultures of leukocytes. Chem.Biol.Interact. 15 205 PMID: 1000726
Shi et al (2011) Alantolactone inhibits cell proliferation by interrupting the interaction between Cripto-1 and AVNreceptor type II A in AVNsignaling pathway. J.Biomol.Screen. 16 525 PMID: 21378277
Pal et al (2010) Activation of caspases and poly (ADP-ribose) polymerase cleavage to induce apoptosis in leukemia HL-60 cellsby Inula racemosa. Toxicol.In Vitro. 24 1599 PMID: 20600805
If you know of a relevant reference for Alantolactone, please let us know.
View Related Products by Target
Keywords: Alantolactone, Alantolactone supplier, antiproliferative, sesquiterpene, lactones, activin, SMAD3, type, II, A, receptors, BMP, and, Other, Activin, Receptors, 4490, Tocris Bioscience
Citations for Alantolactone
Citations are publications that use Tocris products.
Currently there are no citations for Alantolactone. Do you know of a great paper that uses Alantolactone from Tocris? Please let us know.
Reviews for Alantolactone
There are currently no reviews for this product. Be the first to review Alantolactone and earn rewards!
Have you used Alantolactone?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cancer Research Product Guide
A collection of over 750 products for cancer research, the guide includes research tools for the study of:
- Cancer Metabolism
- Epigenetics in Cancer
- Receptor Signaling
- Cell Cycle and DNA Damage Repair
- Angiogenesis
- Invasion and Metastasis
Stem Cell Research Product Guide
This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:
- Self-renewal and Maintenance
- Differentiation
- Reprogramming
- Organoid Generation
- GMP and Ancillary Material Grade Products
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Stem Cell Workflow Poster
Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.
Stem Cells Poster
Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.
Pathways for Alantolactone
