Alantolactone

Pricing Availability Delivery Time Qty
Cat.No. 4490 - Alantolactone | C15H20O2 | CAS No. 546-43-0
Description: Antiproliferative; induces activin/Smad3 signaling
Chemical Name: (3aR,5S,8aR,9aR)-3a,5,6,7,8,8a,9,9a-Octahydro-5,8a-dimethyl-3-methylenenaphtho[2,3-b]furan-2(3H)-one
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature
Pathways

Biological Activity

Sesquiterpene lactone. Induces activin/SMAD3 signaling and disrupts Cripto-1/activin receptor type II A interaction. Displays antiproliferative activity in human colon adenocarcinoma HCT-8 cells.

Compound Libraries

Alantolactone is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 232.32
Formula C15H20O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 546-43-0
PubChem ID 72724
InChI Key PXOYOCNNSUAQNS-AGNJHWRGSA-N
Smiles O=C3C([C@@]2([H])C=C1[C@@H](C)CCC[C@@](C)1C[C@]([H])2O3)=C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 23.23 100
ethanol 23.23 100

Preparing Stock Solutions

The following data is based on the product molecular weight 232.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.3 mL 21.52 mL 43.04 mL
5 mM 0.86 mL 4.3 mL 8.61 mL
10 mM 0.43 mL 2.15 mL 4.3 mL
50 mM 0.09 mL 0.43 mL 0.86 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Dupuis & Brisson et al (1976) Toxic effect of alantolactone and dihydroalantolactone in in vitro cultures of leukocytes. Chem.Biol.Interact. 15 205 PMID: 1000726

Shi et al (2011) Alantolactone inhibits cell proliferation by interrupting the interaction between Cripto-1 and activin receptor type II A in activin signaling pathway. J.Biomol.Screen. 16 525 PMID: 21378277

Pal et al (2010) Activation of caspases and poly (ADP-ribose) polymerase cleavage to induce apoptosis in leukemia HL-60 cellsby Inula racemosa. Toxicol.In Vitro. 24 1599 PMID: 20600805


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Keywords: Alantolactone, supplier, antiproliferative, sesquiterpene, lactones, activin, SMAD3, type, II, A, receptors, BMP, and, Other, Activin, Receptors, Miscellaneous, Compounds, BMP, and, Other, Activin, Receptors, Tocris Bioscience

Citations for Alantolactone

Citations are publications that use Tocris products.

Currently there are no citations for Alantolactone. Do you know of a great paper that uses Alantolactone from Tocris? If so please let us know.

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Reviews

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases

Pathways for Alantolactone

TGF-β

TGF-β Signaling Pathway

The TGF-β signaling pathway is involved in the regulation of growth and proliferation of cells along with migration, differentiation and apoptosis.

Protocols

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