[Ala113]-MBP (104-118)

Pricing Availability Delivery Time Qty
Cat.No. 1901 - [Ala113]-MBP (104-118) | Gly-Lys-Gly-Arg-Gly-Leu-Ser-Leu-Ser-Ala-Phe-Ser-Trp-Gly-Ala | CAS No. 99026-78-5
Description: Protein kinase C inhibitor
Alternative Names: [Ala113]-Myelin Basic Protein (104-118)
Datasheet
Citations
Literature

Biological Activity

Synthetic peptide analog of bovine myelin basic protein (MBP). Non-competitive inhibitor of PKC (IC50 = 28 - 62 mM).

Technical Data

M. Wt 1493.68
Formula C67H104N20O19
Sequence GKGRGLSLSAFSWGA
Storage Desiccate at -20°C
CAS Number 99026-78-5
PubChem ID 71312078
InChI Key FBVMKAAYUXGGSU-NBRSAOMZSA-N
Smiles [H]NCC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)NCC(=O)N[C@@H](C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 2 mg/ml in 0.25% acetic acid

Preparing Stock Solutions

The following data is based on the product molecular weight 1493.68. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.67 mL 3.35 mL 6.69 mL
5 mM 0.13 mL 0.67 mL 1.34 mL
10 mM 0.07 mL 0.33 mL 0.67 mL
50 mM 0.01 mL 0.07 mL 0.13 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Su et al (1986) Synthetic myelin basic protein peptide analogs are specific inhibitors of phospholipid/calcium-dependent protein kinase (protein kinase C). Biochem.Biophys.Res.Commun. 134 78 PMID: 2418828

Turner et al (1985) Substrate specificity of phospholipid/Ca2+ dependent protein kinase as probed with synthetic peptide fragments of the bovine myelin basic protein. J.Biol.Chem. 260 11503 PMID: 2413012


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Citations for [Ala113]-MBP (104-118)

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