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Biological Activity for AI-3
AI-3 is an antioxidant response element (ARE) activator; disrupts Nrf2/Keap1 and Keap1/Cul3 interactions and stabilizes Nrf2. Activates ARE in an Nrf2 and PI 3-kinase dependent manner. Induces cytoprotective gene expression in vitro and in vivo.
Technical Data for AI-3
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for AI-3
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for AI-3
The following data is based on the product molecular weight 292.8. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.42 mL||17.08 mL||34.15 mL|
|5 mM||0.68 mL||3.42 mL||6.83 mL|
|10 mM||0.34 mL||1.71 mL||3.42 mL|
|50 mM||0.07 mL||0.34 mL||0.68 mL|
References for AI-3
References are publications that support the biological activity of the product.
Wang et al (2013) In vitro and in vivo characterization of a tunable dual-reactivity probe of the Nrf2-ARE pathway. ACS Chem.Biol. 8 1764 PMID: 23773140
If you know of a relevant reference for AI-3, please let us know.
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Keywords: AI-3, AI-3 supplier, antioxidant, response, element, ARE, NRF2, Nuclear, factor, (erythroid-derived-2)-like, 2, activators, induces, cytoprotective, gene, expression, keap1, Nrf2, 5145, Tocris Bioscience
Citations for AI-3
Citations are publications that use Tocris products.
Currently there are no citations for AI-3. Do you know of a great paper that uses AI-3 from Tocris? Please let us know.
Reviews for AI-3
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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