AI-3

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Cat.No. 5145 - AI-3 | C11H13ClO3S2 | CAS No. 882288-28-0
Description: ARE activator; induces Nrf2-ARE-dependent transcription
Chemical Name: 1-Chloro-6,7-dihydro-6,6-dimethyl-3-(methylsulfonyl)-benzo[c]thiophen-4(5H)-one
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Antioxidant response element (ARE) activator; disrupts Nrf2/Keap1 and Keap1/Cul3 interactions and stabilizes Nrf2. Activates ARE in an Nrf2 and PI 3-kinase dependent manner. Induces cytoprotective gene expression in vitro and in vivo.

Technical Data

M. Wt 292.8
Formula C11H13ClO3S2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 882288-28-0
PubChem ID 2820824
InChI Key PVJWSALSWFDIMS-UHFFFAOYSA-N
Smiles O=C1CC(C)(C)CC2=C(Cl)SC(S(=O)(C)=O)=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 29.28 100
ethanol 14.64 50

Preparing Stock Solutions

The following data is based on the product molecular weight 292.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.42 mL 17.08 mL 34.15 mL
5 mM 0.68 mL 3.42 mL 6.83 mL
10 mM 0.34 mL 1.71 mL 3.42 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Wang et al (2013) In vitro and in vivo characterization of a tunable dual-reactivity probe of the Nrf2-ARE pathway. ACS Chem.Biol. 8 1764 PMID: 23773140


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Keywords: AI-3, supplier, antioxidant, response, element, ARE, NRF2, Nuclear, factor, (erythroid-derived-2)-like, 2, activators, induces, cytoprotective, gene, expression, keap1, Nrf2, Nrf2, Tocris Bioscience

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