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Biological Activity for AI-3
AI-3 is an antioxidant response element (ARE) activator; disrupts Nrf2/Keap1 and Keap1/Cul3 interactions and stabilizes Nrf2. Activates ARE in an Nrf2 and PI 3-kinase dependent manner. Induces cytoprotective gene expression in vitro and in vivo.
Technical Data for AI-3
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References for AI-3
References are publications that support the biological activity of the product.
Wang et al (2013) In vitro and in vivo characterization of a tunable dual-reactivity probe of the Nrf2-ARE pathway. ACS Chem.Biol. 8 1764 PMID: 23773140
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Keywords: AI-3, AI-3 supplier, antioxidant, response, element, ARE, NRF2, Nuclear, factor, (erythroid-derived-2)-like, 2, activators, induces, cytoprotective, gene, expression, keap1, Nrf2, 5145, Tocris Bioscience
Citations for AI-3
Citations are publications that use Tocris products.
Currently there are no citations for AI-3.
Reviews for AI-3
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Literature in this Area
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