AG 879

Discontinued Product

AG 879 (Cat. No. 2617) has been withdrawn from sale for commercial reasons.
Cat.No. 2617 - AG 879 | C18H24N2OS | CAS No. 148741-30-4
Description: TrkA inhibitor
Alternative Names: Tyrphostin AG 879
Chemical Name: (2E)-3-[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-cyano-2-propenethioamide
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (6)

Biological Activity for AG 879

AG 879 is an inhibitor of the tyrosine kinase activity of nerve growth factor (NGF) TrkA. Decreases cellular proliferation in human muscular sarcoma cell lines. Also inhibits ErbB2 and VEGFR-2 (IC50 values are approximately 1 μM for both).

Technical Data for AG 879

M. Wt 316.46
Formula C18H24N2OS
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 148741-30-4
PubChem ID 5487525
InChI Key LCUMYVYIHXYBIA-FOWTUZBSSA-N
Smiles CC(C)(C)C1=CC(/C=C(C#N)/C(N)=S)=CC(C(C)(C)C)=C1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for AG 879

Certificate of Analysis / Product Datasheet
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1 Citation for AG 879

Citations are publications that use Tocris products. Selected citations for AG 879 include:

Ledonne et al (2015) Neuregulin 1 signalling modulates mGluR1 function in mesencephalic dopaminergic neurons. Mol Psychiatry 20 959 PMID: 25266126


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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