AG 879

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Cat.No. 2617 - AG 879 | C18H24N2OS | CAS No. 148741-30-4
Description: TrkA inhibitor
Alternative Names: Tyrphostin AG 879
Chemical Name: (2E)-3-[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-cyano-2-propenethioamide
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Inhibitor of the tyrosine kinase activity of nerve growth factor (NGF) TrkA. Decreases cellular proliferation in human muscular sarcoma cell lines. Also inhibits ErbB2 and VEGFR-2 (IC50 values are approximately 1 μM for both).

Technical Data

M. Wt 316.46
Formula C18H24N2OS
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 148741-30-4
PubChem ID 5487525
InChI Key LCUMYVYIHXYBIA-FOWTUZBSSA-N
Smiles CC(C)(C)C1=CC(/C=C(C#N)/C(N)=S)=CC(C(C)(C)C)=C1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.65 100
ethanol 7.91 25

Preparing Stock Solutions

The following data is based on the product molecular weight 316.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.16 mL 15.8 mL 31.6 mL
5 mM 0.63 mL 3.16 mL 6.32 mL
10 mM 0.32 mL 1.58 mL 3.16 mL
50 mM 0.06 mL 0.32 mL 0.63 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

He et al (2004) The Tyr-kinase inhibitor AG879, that blocks the ETK-PAK1 interaction, suppresses the RAS-induced PAK1 activation and malignant transformation. Cancer Biol.Ther. 3 96 PMID: 14726663

Rende et al (2006) Role of nerve growth factor and its receptors in non-nervous cancer growth: efficacy of a tyrosine kinase inhibitor (AG879) and neutralizing antibodies antityrosine kinase receptor A and antinerve growth factor: an in-vitro and in-vivo study. Anticancer Drugs 17 929 PMID: 16940803


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Keywords: AG879 tyrosine kinase inhibitors ErbB2 VEGFR-2 EGFR Flk-1 nerve growth factors inhibits NGF TrkA Tyrphostin AG 879 Trk Receptors

Citations for AG 879

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