Epidermal growth factor receptor (EGFR) kinase inhibitor (IC50 = 1.1 μM). Selective over ErbB2 (IC50 > 500 μM).
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 336.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.97 mL||14.86 mL||29.73 mL|
|5 mM||0.59 mL||2.97 mL||5.95 mL|
|10 mM||0.3 mL||1.49 mL||2.97 mL|
|50 mM||0.06 mL||0.3 mL||0.59 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Gamett et al (1997) Secondary dimerization between members of the epidermal growth factor receptor family. J.Biol.Chem. 272 12052 PMID: 9115272
Gazit et al (1991) Tyrphostins. 2. Heterocyclic and α-substituted benzylidenemalononitrile tyrophostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases. J.Med.Chem. 34 1896 PMID: 1676428
If you know of a relevant reference for AG 556, please let us know.
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Keywords: EGFR kinase inhibitors inhibits Epidermal Growth Factors Receptors ErbB Her Receptor Tyrosine Kinases RTKs AG556 Tyrphostin AG 556 Tyrphostin AG 556 EGFR
Citations for AG 556
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