AdipoRon hydrochloride

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Cat.No. 5096 - AdipoRon hydrochloride | C27H28N2O3.HCl | CAS No. 1781835-20-8
Description: Orally active AdipoR1 and AdipoR2 agonist; antidiabetic
Chemical Name: 2-(4-Benzyoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]acetamide hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Agonist of adiponectin receptors AdipoR1 and AdipoR2 (Kd values are 1.8 and 3.1 μM respectively). Activates AMPK and PPARα signaling; ameliorates insulin resistance, dyslipidemia and glucose intolerance in db/db mice. Orally active antidiabetic agent.

Compound Libraries

AdipoRon hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 464.98
Formula C27H28N2O3.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1781835-20-8
PubChem ID 78243714
InChI Key TZVJQEGKRLDTHQ-UHFFFAOYSA-N
Smiles O=C(C2=CC=C(OCC(NC3CCN(CC4=CC=CC=C4)CC3)=O)C=C2)C1=CC=CC=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 46.5 100
ethanol 4.65 10

Preparing Stock Solutions

The following data is based on the product molecular weight 464.98. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.15 mL 10.75 mL 21.51 mL
5 mM 0.43 mL 2.15 mL 4.3 mL
10 mM 0.22 mL 1.08 mL 2.15 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Okada-Iwabu et al (2013) A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity. Nature 503 493 PMID: 24172895


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View Related Products by Target

Keywords: antidiabetic adiponectin receptors ApoR1 ApoR2 agonists orally active Other Peptide Receptors

Citations for AdipoRon hydrochloride

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Literature in this Area

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Peptides Involved in Appetite Modulation

Peptides Involved in Appetite Modulation Scientific Review

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Pathways for AdipoRon hydrochloride

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