AdipoRon hydrochloride

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Cat.No. 5096 - AdipoRon hydrochloride | C27H28N2O3.HCl | CAS No. 1781835-20-8
Description: Orally active AdipoR1 and AdipoR2 agonist; antidiabetic
Chemical Name: 2-(4-Benzyoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]acetamide hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Agonist of adiponectin receptors AdipoR1 and AdipoR2 (Kd values are 1.8 and 3.1 μM respectively). Activates AMPK and PPARα signaling; ameliorates insulin resistance, dyslipidemia and glucose intolerance in db/db mice. Orally active antidiabetic agent.

Compound Libraries

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Technical Data

M. Wt 464.98
Formula C27H28N2O3.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1781835-20-8
PubChem ID 78243714
InChI Key TZVJQEGKRLDTHQ-UHFFFAOYSA-N
Smiles O=C(C2=CC=C(OCC(NC3CCN(CC4=CC=CC=C4)CC3)=O)C=C2)C1=CC=CC=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 4.65 10
DMSO 46.5 100

Preparing Stock Solutions

The following data is based on the product molecular weight 464.98. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.15 mL 10.75 mL 21.51 mL
5 mM 0.43 mL 2.15 mL 4.3 mL
10 mM 0.22 mL 1.08 mL 2.15 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

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References

References are publications that support the biological activity of the product.

Okada-Iwabu et al (2013) A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity. Nature 503 493 PMID: 24172895


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Citations for AdipoRon hydrochloride

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Literature in this Area

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