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Biological Activity for AdipoRon hydrochloride
AdipoRon hydrochloride is an agonist of adiponectin receptors AdipoR1 and AdipoR2 (Kd values are 1.8 and 3.1 μM respectively). Activates AMPK and PPARα signaling; ameliorates insulin resistance, dyslipidemia and glucose intolerance in db/db mice. Orally active antidiabetic agent.
Compound Libraries for AdipoRon hydrochloride
Technical Data for AdipoRon hydrochloride
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for AdipoRon hydrochloride
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for AdipoRon hydrochloride
The following data is based on the product molecular weight 464.98. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.15 mL||10.75 mL||21.51 mL|
|5 mM||0.43 mL||2.15 mL||4.3 mL|
|10 mM||0.22 mL||1.08 mL||2.15 mL|
|50 mM||0.04 mL||0.22 mL||0.43 mL|
Product Datasheets for AdipoRon hydrochloride
References for AdipoRon hydrochloride
References are publications that support the biological activity of the product.
Okada-Iwabu et al (2013) A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity. Nature 503 493 PMID: 24172895
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1 Citation for AdipoRon hydrochloride
Citations are publications that use Tocris products. Selected citations for AdipoRon hydrochloride include:
Sung et al (2019) Iron induces ins. resistance in cardiomyocytes via regulation of oxidative stress. Sci Rep 9 4668 PMID: 30874600
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.