Adenosine 5'-(α,β-methylene)diphosphate sodium salt

Pricing Availability   Qty
Description: Ecto-5'-nucleotidase (CD73) inhibitor
Alternative Names: AMPCP,APCP
Chemical Name: α,β-Methyleneadenosine 5'-diphosphate monosodium salt
Purity: ≥98% (HPLC)
Citations (4)
Reviews (1)
Literature (1)

Biological Activity

Adenosine 5'-(α,β-methylene)diphosphate sodium salt is an ecto-5'-nucleotidase/CD73 inhibitor. Blocks ecto-5'-nucleotidase-mediated adenosine production by preventing the conversion of AMP to adenosine. Reverses the doxorubicin-resistance in ecto-5'-nucleotidase-positive MDR cells (MCF7/A6 and L1210/A). Also increases rhodamine uptake and inhibits rhodamine efflux from ecto-5'-nucleotidase-positive MDR cells. Vasoconstrictor.

Technical Data

M. Wt 447.21
Formula C11H16N5NaO9P2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 89016-30-8
PubChem ID 91691113
Smiles NC1=C2C(N([C@@H]3O[C@H](COP(CP(O)(O[Na])=O)(O)=O)[C@@H](O)[C@@H]3O)C=N2)=NC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble in water (supplied pre-dissolved at a concentration of 10mM)

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:


References are publications that support the biological activity of the product.

Niemelä et al (2008) IFN-beta regulates CD73 and adenosine expression at the blood-brain barrier. Eur.J.Immunol. 38 2718 PMID: 18825744

Kur et al (2014) Purinergic control of vascular tone in the retina. J.Physiol. 592 491 PMID: 24277867

Ujházy et al (1996) Evidence for the involvement of ecto-5'-nucleotidase (CD73) in drug resistance. Int.J.Cancer. 68 493 PMID: 8945621

Chen et al (2019) Asthmatic augmentation of airway vagal activity involves decreased central expression and activity of CD73 in rats. ACS Chem.Neurosci. 10 2809 PMID: 30913879

If you know of a relevant reference for Adenosine 5'-(α,β-methylene)diphosphate sodium salt, please let us know.

View Related Products by Target

View Related Products by Product Action

View all NTPDase Inhibitors

Keywords: Adenosine 5'-(a,b-methylene)diphosphate sodium salt, Adenosine 5'-(a,b-methylene)diphosphate sodium salt supplier, [3768-14-7], MS, multiple, sclerosis, Ecto-5'-nucleotidase/, CD73, inhibitors, inhibits, adenosine, doxorubicin-resistance, vasoconstrictor, NT5E, eN, eNT, 5', nucleotidase, ecto-5'-NT, 5-(a,b-methylene)diphosphate, AMPCP, APCP, NTPDase, 3633, Tocris Bioscience

4 Citations for Adenosine 5'-(α,β-methylene)diphosphate sodium salt

Citations are publications that use Tocris products. Selected citations for Adenosine 5'-(α,β-methylene)diphosphate sodium salt include:

Yu et al (2022) Potential roles of serum ATPase and AMPase in predicting diagnosis of colorectal cancer patients. Bioengineered 13 14204-14214 PMID: 35754345

Thomas et al (2020) Inhibition of Adenosine Pathway Alters Atrial Electrophysiology and Prevents Atrial Fibrillation. Front Physiol 11 493 PMID: 32595514

Wu et al (2018) Borneol and α-asarone as adjuvant agents for improving blood-brain barrier permeability of puerarin and tetramethylpyrazine by activating adenosine receptors. Drug Deliv 25 1858 PMID: 30338713

Caiazzo et al (2016) Adenosine signalling mediates the anti-inflammatory effects of the COX-2 inhibitor nimesulide. Biochem.Pharmacol. 112 72 PMID: 27188793

Do you know of a great paper that uses Adenosine 5'-(α,β-methylene)diphosphate sodium salt from Tocris? Please let us know.

Reviews for Adenosine 5'-(α,β-methylene)diphosphate sodium salt

Average Rating: 5 (Based on 1 Review.)

5 Star
4 Star
3 Star
2 Star
1 Star

Have you used Adenosine 5'-(α,β-methylene)diphosphate sodium salt?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:

Inhibited CD73 activity in TCRgd T cells completely.
By Anonymous on 06/05/2018
Assay Type: In Vitro
Species: Mouse

Perfect for inhibiting CD73 activity in TCRgd T cells. TCRgd T cells express enzymatically active CD73 on their surface. CD73 activity was detected by the converting of AMP to adenosine which was completely blocked by APCP.

review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

P2X and P2Y Receptors Scientific Review

P2X and P2Y Receptors Scientific Review

Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.