Adenosine 5'-(α,β-methylene)diphosphate sodium salt
Ecto-5'-nucleotidase/CD73 inhibitor. Blocks ecto-5'-nucleotidase-mediated adenosine production by preventing the conversion of AMP to adenosine. Reverses the doxorubicin-resistance in ecto-5'-nucleotidase-positive MDR cells (MCF7/A6 and L1210/A). Also increases rhodamine uptake and inhibits rhodamine efflux from ecto-5'-nucleotidase-positive MDR cells. Vasoconstrictor.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble in water (supplied pre-dissolved at a concentration of 10mM)|
Preparing Stock Solutions
The following data is based on the product molecular weight 447.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.24 mL||11.18 mL||22.36 mL|
|5 mM||0.45 mL||2.24 mL||4.47 mL|
|10 mM||0.22 mL||1.12 mL||2.24 mL|
|50 mM||0.04 mL||0.22 mL||0.45 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Niemelä et al (2008) IFN-beta regulates CD73 and adenosine expression at the blood-brain barrier. Eur.J.Immunol. 38 2718 PMID: 18825744
Kur et al (2014) Purinergic control of vascular tone in the retina. J.Physiol. 592 491 PMID: 24277867
Ujházy et al (1996) Evidence for the involvement of ecto-5'-nucleotidase (CD73) in drug resistance. Int.J.Cancer. 68 493 PMID: 8945621
If you know of a relevant reference for Adenosine 5'-(α,β-methylene)diphosphate sodium salt, please let us know.
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Keywords: [3768-14-7] MS multiple sclerosis Ecto-5'-nucleotidase/ CD73 inhibitors inhibits adenosine doxorubicin-resistance vasoconstrictor NT5E eN eNT 5' nucleotidase ecto-5'-NT 5-(a,b-methylene)diphosphate AMPCP APCP NTPDase
1 Citation for Adenosine 5'-(α,β-methylene)diphosphate sodium salt
Citations are publications that use Tocris products. Selected citations for Adenosine 5'-(α,β-methylene)diphosphate sodium salt include:
Caiazzo et al (2016) Adenosine signalling mediates the anti-inflammatory effects of the COX-2 inhibitor nimesulide. Biochem.Pharmacol. 112 72 PMID: 27188793
Do you know of a great paper that uses Adenosine 5'-(α,β-methylene)diphosphate sodium salt from Tocris? If so please let us know.
Literature in this Area
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