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High affinity adenine receptor agonist (Ki = 18 nM at rat adenine receptor). Inhibits forskolin-stimulated cAMP formation in CHO cells transfected with the adenine receptor; also stimulates GTPγS binding (pEC50 values are 8.54 and 7.21 respectively).
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 171.59. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||5.83 mL||29.14 mL||58.28 mL|
|5 mM||1.17 mL||5.83 mL||11.66 mL|
|10 mM||0.58 mL||2.91 mL||5.83 mL|
|50 mM||0.12 mL||0.58 mL||1.17 mL|
References are publications that support the biological activity of the product.
Gorzalka et al (2005) Evidence for the functional expression and pharmacological characterization of adenine receptors in native cells and tissues. Mol.Pharmacol. 67 955 PMID: 15604413
Bender et al (2002) Characterization of an orphan G protein-coupled receptor localized in the dorsal root ganglia reveals adenine as a signaling molecule. Proc.Natl.Acad.Sci. 99 8573
If you know of a relevant reference for Adenine, please let us know.
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Keywords: Adenine, Adenine supplier, p0, receptors, agonists, purinergic, signaling, signalling, Adenine, Receptor, 4202, Tocris Bioscience
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