Adenine

Pricing Availability   Qty
Cat.No. 4202 - Adenine | C5H5N5.HCl | CAS No. 6055-72-7
Description: Adenine receptor agonist
Chemical Name: 6-Aminopurine hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity

High affinity adenine receptor agonist (Ki = 18 nM at rat adenine receptor). Inhibits forskolin-stimulated cAMP formation in CHO cells transfected with the adenine receptor; also stimulates GTPγS binding (pEC50 values are 8.54 and 7.21 respectively).

Technical Data

M. Wt 171.59
Formula C5H5N5.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 6055-72-7
PubChem ID 76219
InChI Key UQVDQSWZQXDUJB-UHFFFAOYSA-N
Smiles NC1=C2C(NC=N2)=NC=N1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 17.16 100
DMSO 17.16 100

Preparing Stock Solutions

The following data is based on the product molecular weight 171.59. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.83 mL 29.14 mL 58.28 mL
5 mM 1.17 mL 5.83 mL 11.66 mL
10 mM 0.58 mL 2.91 mL 5.83 mL
50 mM 0.12 mL 0.58 mL 1.17 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References

References are publications that support the biological activity of the product.

Gorzalka et al (2005) Evidence for the functional expression and pharmacological characterization of adenine receptors in native cells and tissues. Mol.Pharmacol. 67 955 PMID: 15604413

Bender et al (2002) Characterization of an orphan G protein-coupled receptor localized in the dorsal root ganglia reveals adenine as a signaling molecule. Proc.Natl.Acad.Sci. 99 8573


If you know of a relevant reference for Adenine, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Adenine Receptor Agonists

Keywords: Adenine, Adenine supplier, p0, receptors, agonists, purinergic, signaling, signalling, Adenine, Receptor, 4202, Tocris Bioscience

Citations for Adenine

Citations are publications that use Tocris products.

Currently there are no citations for Adenine. Do you know of a great paper that uses Adenine from Tocris? Please let us know.

Reviews for Adenine

There are currently no reviews for this product. Be the first to review Adenine and earn rewards!

Have you used Adenine?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


P2X and P2Y Receptors

P2X and P2Y Receptors Scientific Review

Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.