Adenine

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Cat.No. 4202 - Adenine | C5H5N5.HCl | CAS No. 6055-72-7
Description: Adenine receptor agonist
Chemical Name: 6-Aminopurine hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

High affinity adenine receptor agonist (Ki = 18 nM at rat adenine receptor). Inhibits forskolin-stimulated cAMP formation in CHO cells transfected with the adenine receptor; also stimulates GTPγS binding (pEC50 values are 8.54 and 7.21 respectively).

Technical Data

M. Wt 171.59
Formula C5H5N5.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 6055-72-7
PubChem ID 76219
InChI Key UQVDQSWZQXDUJB-UHFFFAOYSA-N
Smiles NC1=C2C(NC=N2)=NC=N1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 17.16 100
water 17.16 100

Preparing Stock Solutions

The following data is based on the product molecular weight 171.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.83 mL 29.14 mL 58.28 mL
5 mM 1.17 mL 5.83 mL 11.66 mL
10 mM 0.58 mL 2.91 mL 5.83 mL
50 mM 0.12 mL 0.58 mL 1.17 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Gorzalka et al (2005) Evidence for the functional expression and pharmacological characterization of adenine receptors in native cells and tissues. Mol.Pharmacol. 67 955 PMID: 15604413

Bender et al (2002) Characterization of an orphan G protein-coupled receptor localized in the dorsal root ganglia reveals adenine as a signaling molecule. Proc.Natl.Acad.Sci. 99 8573 PMID:


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Keywords: Adenine, supplier, p0, receptors, agonists, purinergic, signaling, signalling, Adenine, Receptor, Tocris Bioscience

Citations for Adenine

Citations are publications that use Tocris products.

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Literature in this Area

P2X and P2Y Receptors

P2X and P2Y Receptors Scientific Review

Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.

Pathways for Adenine

Protocols

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