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Description: Adenine receptor agonist
Chemical Name: 6-Aminopurine hydrochloride
Purity: ≥99% (HPLC)
Literature (1)

Biological Activity for Adenine

Adenine is a high affinity adenine receptor agonist (Ki = 18 nM at rat adenine receptor). Inhibits forskolin-stimulated cAMP formation in CHO cells transfected with the adenine receptor; also stimulates GTPγS binding (pEC50 values are 8.54 and 7.21 respectively).

Technical Data for Adenine

M. Wt 171.59
Formula C5H5N5.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 2922-28-3
PubChem ID 76219
Smiles NC1=C2C(NC=N2)=NC=N1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Adenine

Solvent Max Conc. mg/mL Max Conc. mM
water 17.16 100
DMSO 17.16 100

Preparing Stock Solutions for Adenine

The following data is based on the product molecular weight 171.59. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.83 mL 29.14 mL 58.28 mL
5 mM 1.17 mL 5.83 mL 11.66 mL
10 mM 0.58 mL 2.91 mL 5.83 mL
50 mM 0.12 mL 0.58 mL 1.17 mL

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References for Adenine

References are publications that support the biological activity of the product.

Gorzalka et al (2005) Evidence for the functional expression and pharmacological characterization of adenine receptors in native cells and tissues. Mol.Pharmacol. 67 955 PMID: 15604413

Bender et al (2002) Characterization of an orphan G protein-coupled receptor localized in the dorsal root ganglia reveals adenine as a signaling molecule. Proc.Natl.Acad.Sci. 99 8573

If you know of a relevant reference for Adenine, please let us know.

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Keywords: Adenine, Adenine supplier, p0, receptors, agonists, purinergic, signaling, signalling, Adenine, Receptor, 4202, Tocris Bioscience

Citations for Adenine

Citations are publications that use Tocris products.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

P2X and P2Y Receptors Scientific Review

P2X and P2Y Receptors Scientific Review

Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.