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Cat.No. 3716 - Adaphostin | C24H27NO4 | CAS No. 241127-58-2
Description: p210bcr/abl kinase inhibitor
Alternative Names: NSC 680410
Chemical Name: 4-[[(2,5-Dihydroxyphenyl)methyl]amino]benzoic acid tricyclo[,7]dec-1-yl ester
Purity: ≥98% (HPLC)
Citations (1)

Biological Activity

p210bcr/abl tyrosine kinase inhibitor (IC50 = 14 μM). Induces apoptosis in T-lymphoblastic human leukemia cell lines (IC50 values range from 16.8 to 216.3 nM) in vitro. Displays selectivity for chronic myelogenous leukemia (CML) myeloid progenitors in vitro.

Technical Data

M. Wt 393.48
Formula C24H27NO4
Storage Desiccate at +4°C
Purity ≥98% (HPLC)
CAS Number 241127-58-2
PubChem ID 387042
Smiles O=C(C4=CC=C(NCC5=C(O)C=CC(O)=C5)C=C4)OC12CC(C3)CC(CC3C2)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 39.35 100
ethanol 39.35 100

Preparing Stock Solutions

The following data is based on the product molecular weight 393.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.54 mL 12.71 mL 25.41 mL
5 mM 0.51 mL 2.54 mL 5.08 mL
10 mM 0.25 mL 1.27 mL 2.54 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

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References are publications that support the biological activity of the product.

Svingen et al (2000) Effects of the bcl/abl kinase inhibitors AG957 and NSC 680410 on chronic myelogenous leukemia cells in vitro. Clin.Cancer Res. 6 237 PMID: 10656455

Avramis et al (2002) In vitro and in vivo evaluations of the tyrosine kinase inhibitor NSC 680410 against human leukemia and glioblastoma cell lines. Cancer Chemother.Pharmacol. 50 479 PMID: 12451475

Mow et al (2002) Effects of bcr/abl kinase inhibitors STI571 and adaphostin (NSC 680410) on chronic myelogenous leukemia cells in vitro. Blood 99 664 PMID: 11781252

If you know of a relevant reference for Adaphostin, please let us know.

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1 Citation for Adaphostin

Citations are publications that use Tocris products. Selected citations for Adaphostin include:

Xia et al (2014) EZH2 silencing with RNA interference induces G2/M arrest in human lung cancer cells in vitro. Biomed Res Int 2014 348728 PMID: 24745014

Do you know of a great paper that uses Adaphostin from Tocris? Please let us know.

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Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

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