Adapalene

Pricing Availability Delivery Time Qty
Cat.No. 2852 - Adapalene | C28H28O3 | CAS No. 106685-40-9
Description: RARβ and RARγ agonist
Alternative Names: CD 271, Differin
Chemical Name: 6-(4-Methoxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)-2-naphthalenecarboxylic acid
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Retinoic acid analog that is a RARβ and RARγ agonist (AC50 values are 2.2, 9.3, 22 and > 1000 nM for RARβ, RARγ, RARα and RXRα receptors respectively). Inhibits proliferation and induces apoptosis in colorectal cancer cell in vitro. Displays comedolytic activity.

Compound Libraries

Adapalene is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 412.52
Formula C28H28O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 106685-40-9
PubChem ID 60164
InChI Key LZCDAPDGXCYOEH-UHFFFAOYSA-N
Smiles COC1=CC=C(C3=CC=C(C=C(C(O)=O)C=C4)C4=C3)C=C1C25CC(C6)CC(CC6C5)C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 10.31 25

Preparing Stock Solutions

The following data is based on the product molecular weight 412.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.42 mL 12.12 mL 24.24 mL
5 mM 0.48 mL 2.42 mL 4.85 mL
10 mM 0.24 mL 1.21 mL 2.42 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Shroot et al (1997) Pharmacology and chemistry of adapalene. J.Am.Acad.Dermatol. 36 S96 PMID: 9204085

Millikan (2000) Adapalene: an update on newer comparative studies between the various retinoids. Int.J.Dermatol. 39 784 PMID: 11095202

Ocker et al (2003) The synthetic retinoid adapalene inhibits proliferation and induces apoptosis in colorectal cancer cells in vitro. Int.J.Cancer 107 453 PMID: 14506747


If you know of a relevant reference for Adapalene, please let us know.

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View all Retinoic Acid Receptor Agonists

Keywords: RARβ RARbeta RARγ RARgamma agonists Retinoic Acid Receptors CD271 CD 271 Differin Retinoic Acid Receptors

1 Citation for Adapalene

Citations are publications that use Tocris products. Selected citations for Adapalene include:

Dhandapani et al (2011) Retinoic acid enhances TRAIL-induced apoptosis in cancer cells by upregulating TRAIL receptor 1 expression. Drug Des Devel Ther 71 5245 PMID: 21685476


Do you know of a great paper that uses Adapalene from Tocris? If so please let us know.

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Reviews

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Literature in this Area

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  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
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Nuclear Receptors Product Listing

A collection of over 150 products for key nuclear receptors, the listing includes research tools for the study of:

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Retinoid Receptors

Retinoid Receptors Scientific Review

Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.

Pathways for Adapalene

Protocols

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