Neuronal nicotinic receptor antagonist that displays selectivity for the α9α10 subtype (IC50 values are 19, 140, 980, 4200 and 7300 nM for α9α10, α6/α3β2β3, α6/α3β4, α3β4 and α3β2 subtypes respectively). Alleviates neuropathic pain in three rat models of human neuropathic pain and accelerates functional recovery of injured neurons.
Sold under license from Dr Bruce Livett
(Modifications: Cys-16 - C-terminal amide, Disulfide bridge between 2 - 8, 3 - 16)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Preparing Stock Solutions
The following data is based on the product molecular weight 1806.98. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.55 mL||2.77 mL||5.53 mL|
|5 mM||0.11 mL||0.55 mL||1.11 mL|
|10 mM||0.06 mL||0.28 mL||0.55 mL|
|50 mM||0.01 mL||0.06 mL||0.11 mL|
References are publications that support the products' biological activity.
Sandall et al (2003) A novel α-conotoxin identified by gene sequencing is active in suppressing the vascular response to selective stimulation of sensory nerves in vivo. Biochemistry 42 6904 PMID: 12779345
Nevin et al (2007) Are α9α10 nicotinic acetylcholine receptors a pain target for α-conotoxins? Mol.Pharmacol 72 1406 PMID: 17804600
Halai et al (2009) Scanning mutagenesis of α-conotoxin Vc1.1 reveals residues crucial for activity at the α9α10 nicotinic acetylcholine receptor J.Biol.Chem. 284 20275 PMID: 19447885
If you know of a relevant reference for ACV 1, please let us know.
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Keywords: ACV 1, supplier, α9α10, alpha9alpha10, selective, a9, a10, antagonists, Acetylcholine, Nicotinic, Receptors, Non-Selective, Subtypes, nAChR, ACV1, ConotoxinVc11, venoms, Conotoxin, Vc1.1, Nicotinic, Receptors, (Other, Subtypes), Nicotinic, Receptors, (Other, Subtypes), Tocris Bioscience
1 Citation for ACV 1
Citations are publications that use Tocris products. Selected citations for ACV 1 include:
Zachary and Fuchs (2015) Re-Emergent Inhibition of Cochlear Inner Hair Cells in a Mouse Model of Hearing Loss. J Neurosci 35 9701 PMID: 26134652
Do you know of a great paper that uses ACV 1 from Tocris? If so please let us know.
ACV 1 Reviews
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Literature in this Area
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.