ACV 1

Pricing Availability Delivery Time Qty
Cat.No. 3205 - ACV 1 | Gly-Cys-Cys-Ser-Asp-Pro-Arg-Cys-Asn-Tyr-Asp-His-Pro-Glu-Ile-Cys-NH2 | CAS No. 740980-24-9
Description: α9α10-selective antagonist
Alternative Names: Conotoxin Vc1.1
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Neuronal nicotinic receptor antagonist that displays selectivity for the α9α10 subtype (IC50 values are 19, 140, 980, 4200 and 7300 nM for α9α10, α6/α3β2β3, α6/α3β4, α3β4 and α3β2 subtypes respectively). Alleviates neuropathic pain in three rat models of human neuropathic pain and accelerates functional recovery of injured neurons.

Licensing Information

Sold under license from Dr Bruce Livett

Technical Data

M. Wt 1806.98
Formula C71H103N23O25S4
Sequence GCCSDPRCNYDHPEIC

(Modifications: Cys-16 - C-terminal amide, Disulfide bridge between 2 - 8, 3 - 16)

Storage Store at -20°C
CAS Number 740980-24-9
PubChem ID 76321093
InChI Key KJQOYUHYAZGPIZ-PIJHVLQJSA-N
Smiles [H]NCC(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CC3=CNC=N3)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC3=CC=C(O)C=C3)NC(=O)[C@H](CC(N)=O)NC2=O)[C@@H](C)CC)C(N)=O)NC1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Sandall et al (2003) A novel α-conotoxin identified by gene sequencing is active in suppressing the vascular response to selective stimulation of sensory nerves in vivo. Biochemistry 42 6904 PMID: 12779345

Nevin et al (2007) Are α9α10 nicotinic acetylcholine receptors a pain target for α-conotoxins? Mol.Pharmacol 72 1406 PMID: 17804600

Halai et al (2009) Scanning mutagenesis of α-conotoxin Vc1.1 reveals residues crucial for activity at the α9α10 nicotinic acetylcholine receptor J.Biol.Chem. 284 20275 PMID: 19447885

Vincler et al (2006) Molecular mechanism for analgesia involving specific antagonism of α9α10 nicotinic acetylcholine receptors. Proc.Nat.Acad.Sci.USA 103 17880 PMID:


If you know of a relevant reference for ACV 1, please let us know.

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1 Citation for ACV 1

Citations are publications that use Tocris products. Selected citations for ACV 1 include:

Zachary and Fuchs (2015) Re-Emergent Inhibition of Cochlear Inner Hair Cells in a Mouse Model of Hearing Loss. J Neurosci 35 9701 PMID: 26134652


Do you know of a great paper that uses ACV 1 from Tocris? If so please let us know.

Reviews for ACV 1

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Pain

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
Nicotinic ACh Receptors

Nicotinic ACh Receptors Scientific Review

Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.

Pain

Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.