ACV 1

Pricing Availability Delivery Time Qty
Cat.No. 3205 - ACV 1 | Gly-Cys-Cys-Ser-Asp-Pro-Arg-Cys-Asn-Tyr-Asp-His-Pro-Glu-Ile-Cys-NH2 | CAS No. 740980-24-9
Description: α9α10-selective antagonist
Alternative Names: Conotoxin Vc1.1
Datasheet
Citations (1)
Literature

Biological Activity

Neuronal nicotinic receptor antagonist that displays selectivity for the α9α10 subtype (IC50 values are 19, 140, 980, 4200 and 7300 nM for α9α10, α6/α3β2β3, α6/α3β4, α3β4 and α3β2 subtypes respectively). Alleviates neuropathic pain in three rat models of human neuropathic pain and accelerates functional recovery of injured neurons.

Licensing Information

Sold under license from Dr Bruce Livett

Technical Data

M. Wt 1806.98
Formula C71H103N23O25S4
Sequence GCCSDPRCNYDHPEIC

(Modifications: Cys-16 - C-terminal amide, Disulfide bridge between 2 - 8, 3 - 16)

Storage Store at -20°C
CAS Number 740980-24-9
PubChem ID 76321093
InChI Key KJQOYUHYAZGPIZ-PIJHVLQJSA-N
Smiles [H]NCC(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CC3=CNC=N3)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC3=CC=C(O)C=C3)NC(=O)[C@H](CC(N)=O)NC2=O)[C@@H](C)CC)C(N)=O)NC1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 1806.98. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.55 mL 2.77 mL 5.53 mL
5 mM 0.11 mL 0.55 mL 1.11 mL
10 mM 0.06 mL 0.28 mL 0.55 mL
50 mM 0.01 mL 0.06 mL 0.11 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Sandall et al (2003) A novel α-conotoxin identified by gene sequencing is active in suppressing the vascular response to selective stimulation of sensory nerves in vivo. Biochemistry 42 6904 PMID: 12779345

Nevin et al (2007) Are α9α10 nicotinic acetylcholine receptors a pain target for α-conotoxins? Mol.Pharmacol 72 1406 PMID: 17804600

Halai et al (2009) Scanning mutagenesis of α-conotoxin Vc1.1 reveals residues crucial for activity at the α9α10 nicotinic acetylcholine receptor J.Biol.Chem. 284 20275 PMID: 19447885

Vincler et al (2006) Molecular mechanism for analgesia involving specific antagonism of α9α10 nicotinic acetylcholine receptors. Proc.Nat.Acad.Sci.USA 103 17880 PMID:


If you know of a relevant reference for ACV 1, please let us know.

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Keywords: ACV 1, supplier, α9α10, alpha9alpha10, selective, a9, a10, antagonists, Acetylcholine, Nicotinic, Receptors, Non-Selective, Subtypes, nAChR, ACV1, ConotoxinVc11, venoms, Conotoxin, Vc1.1, Nicotinic, Receptors, (Other, Subtypes), Nicotinic, Receptors, (Other, Subtypes), Tocris Bioscience

1 Citation for ACV 1

Citations are publications that use Tocris products. Selected citations for ACV 1 include:

Zachary and Fuchs (2015) Re-Emergent Inhibition of Cochlear Inner Hair Cells in a Mouse Model of Hearing Loss. J Neurosci 35 9701 PMID: 26134652


Do you know of a great paper that uses ACV 1 from Tocris? If so please let us know.

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