Competitive metabotropic receptor antagonist (KB values are 115, 88 and 77 μM at mGlu1a, mGlu2 and mGlu4a respectively).
Sold with the permission of the CNRS
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 5 mM in DMSO and to 100 mM in 1.4 eq. NaOH|
Preparing Stock Solutions
The following data is based on the product molecular weight 217.18. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.6 mL||23.02 mL||46.04 mL|
|5 mM||0.92 mL||4.6 mL||9.21 mL|
|10 mM||0.46 mL||2.3 mL||4.6 mL|
|50 mM||0.09 mL||0.46 mL||0.92 mL|
References are publications that support the products' biological activity.
Acher et al (1997) Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor subtypes. J.Med.Chem. 40 3119 PMID: 9301676
Bessis et al (2002) Closure of the venus flytrap model of mGlu8 receptor and the activation process: Insights from mutations converting antagonists into agonists. Proc.Natl.Acad.Sci.U.S.A. 99 11097 PMID: 12151600
If you know of a relevant reference for ACPT-II, please let us know.
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Keywords: ACPT-II, supplier, Competitive, receptor, antagonists, Non-Selective, Receptors, Metabotropic, Glutamate, Non-selective, mGlu, Non-selective, mGlu, Tocris Bioscience
2 Citations for ACPT-II
Citations are publications that use Tocris products. Selected citations for ACPT-II include:
Casado et al (2000) Presynaptic N-methyl-D-aspartate receptors at the parallel fiber-Purkinje cell synapse. Int J Mol Sci 97 11593 PMID: 11016958
Scholler (2017) HTS-compatible FRET-based conformational sensors clarify membrane receptor activation. Nat Chem Biol 13 372 PMID: 28135236
Do you know of a great paper that uses ACPT-II from Tocris? If so please let us know.
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