ACPT-II

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Cat.No. 1112 - ACPT-II | C8H11NO6 | CAS No. 195209-04-2
Description: Competitive mGlu receptor antagonist
Chemical Name: (1R,3R,4S)-1-Aminocyclopentane-1,3,4-tricarboxylic acid
Datasheet
Citations (1)
Literature

Biological Activity

Competitive metabotropic receptor antagonist (KB values are 115, 88 and 77 μM at mGlu1a, mGlu2 and mGlu4a respectively).

Licensing Information

Sold with the permission of the CNRS

Technical Data

M. Wt 217.18
Formula C8H11NO6
Storage Desiccate at -20°C
CAS Number 195209-04-2
PubChem ID 5280961
InChI Key TZBJGXHYKVUXJN-UHFFFAOYSA-N
Smiles N[C@]1([C@@](O)=O)C[C@H]([C@](O)=O)[C@H]([C@@](O)=O)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 5 mM in DMSO and to 100 mM in 1.4 eq. NaOH

Preparing Stock Solutions

The following data is based on the product molecular weight 217.18. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.6 mL 23.02 mL 46.04 mL
5 mM 0.92 mL 4.6 mL 9.21 mL
10 mM 0.46 mL 2.3 mL 4.6 mL
50 mM 0.09 mL 0.46 mL 0.92 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Acher et al (1997) Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor subtypes. J.Med.Chem. 40 3119 PMID: 9301676

Bessis et al (2002) Closure of the venus flytrap model of mGlu8 receptor and the activation process: Insights from mutations converting antagonists into agonists. Proc.Natl.Acad.Sci.U.S.A. 99 11097 PMID: 12151600


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Keywords: ACPT-II, supplier, Competitive, receptor, antagonists, Non-Selective, Receptors, Metabotropic, Glutamate, Non-selective, mGlu, Tocris Bioscience

1 Citation for ACPT-II

Citations are publications that use Tocris products. Selected citations for ACPT-II include:

Casado et al (2000) Presynaptic N-methyl-D-aspartate receptors at the parallel fiber-Purkinje cell synapse. Int J Mol Sci 97 11593 PMID: 11016958


Do you know of a great paper that uses ACPT-II from Tocris? If so please let us know.

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Pathways for ACPT-II

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