ACPT-II

Discontinued Product

ACPT-II (Cat. No. 1112) has been withdrawn from sale for commercial reasons.
Description: Competitive mGlu receptor antagonist
Chemical Name: (1R,3R,4S)-1-Aminocyclopentane-1,3,4-tricarboxylic acid
Datasheet
Citations (2)
Reviews
Literature (2)

Biological Activity for ACPT-II

ACPT-II is a competitive metabotropic receptor antagonist (KB values are 115, 88 and 77 μM at mGlu1a, mGlu2 and mGlu4a respectively).

Licensing Information

Sold with the permission of the CNRS

Technical Data for ACPT-II

M. Wt 217.18
Formula C8H11NO6
Storage Desiccate at -20°C
CAS Number 195209-04-2
PubChem ID 6604820
InChI Key FERIKTBTNCSGJS-OBLUMXEWSA-N
Smiles N[C@]1([C@@](O)=O)C[C@H]([C@](O)=O)[C@H]([C@@](O)=O)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for ACPT-II

References are publications that support the biological activity of the product.

Acher et al (1997) Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor subtypes. J.Med.Chem. 40 3119 PMID: 9301676

Bessis et al (2002) Closure of the venus flytrap model of mGlu8 receptor and the activation process: Insights from mutations converting antagonists into agonists. Proc.Natl.Acad.Sci.U.S.A. 99 11097 PMID: 12151600

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Keywords: ACPT-II, ACPT-II supplier, Competitive, receptor, antagonists, Non-Selective, Receptors, Metabotropic, Glutamate, Non-selective, mGlu, 1112, Tocris Bioscience

2 Citations for ACPT-II

Citations are publications that use Tocris products. Selected citations for ACPT-II include:

Casado et al (2000) Presynaptic N-MthD.-aspartate receptors at the parallel fiber-Purkinje cell synapse. Int J Mol Sci 97 11593 PMID: 11016958

Scholler (2017) HTS-compatible FRET-based conformational sensors clarify membrane receptor activation. Nat Chem Biol 13 372 PMID: 28135236


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Metabotropic Glutamate Receptors Scientific Review

Metabotropic Glutamate Receptors Scientific Review

Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.