ACET

Pricing Availability Delivery Time Qty
Cat.No. 2728 - ACET | C20H19N3O6S | CAS No. 936095-50-0
Description: Potent antagonist of GluR5-containing kainate receptors
Chemical Name: (S)-1-(2-Amino-2-carboxyethyl)-3-(2-carboxy-5-phenylthiophene-3-yl-methyl)-5-methylpyrimidine-2,4-dione
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Potent and selective GluR5-containing kainate receptor antagonist (IC50 = 7 nM) that displays selectivity over GluR6-containing kainate, NMDA, AMPA and group I mGlu receptors. Reversibly blocks induction of NMDA receptor-independent long term potentiation (LTP) in vitro at nanomolar concentrations.

Technical Data

M. Wt 429.45
Formula C20H19N3O6S
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 936095-50-0
PubChem ID 16125102
InChI Key LCZDCKMQSBGXAH-AWEZNQCLSA-N
Smiles O=C(C(C)=CN1C[C@@H](C(O)=O)N)N(CC2=C(C(O)=O)SC(C3=CC=CC=C3)=C2)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
3eq. NaOH 8.59 20

Preparing Stock Solutions

The following data is based on the product molecular weight 429.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.33 mL 11.64 mL 23.29 mL
5 mM 0.47 mL 2.33 mL 4.66 mL
10 mM 0.23 mL 1.16 mL 2.33 mL
50 mM 0.05 mL 0.23 mL 0.47 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Dolman et al (2007) Synthesis and pharmacological characterisation of N3-substituted willardiine derivatives: role of the substituent at the 5-position of the uracil ring in the development of highly potent and selective GLUK5 kainate receptor antagonis J.Med.Chem. 50 1558 PMID: 17348638

Dargan et al (2009) ACET is a highly potent and specific kainate receptor antagonist: Characterisation and effects on hippocampal mossy fibre function. Neuropharmacology 56 121 PMID: 18789344


If you know of a relevant reference for ACET, please let us know.

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Keywords: ACET, supplier, Potent, antagonists, GluR5-containing, kainate, receptors, Glutamate, Kainate, Receptors, iGluR, Ionotropic, Kainate, Receptors, Kainate, Receptors, Tocris Bioscience

1 Citation for ACET

Citations are publications that use Tocris products. Selected citations for ACET include:

Granger and Nicoll (2014) LTD expression is independent of glutamate receptor subtype. J Virol 6 15 PMID: 25071549


Do you know of a great paper that uses ACET from Tocris? If so please let us know.

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