Acein

Pricing Availability   Qty
Cat.No. 6006 - Acein | Pro-Pro-Thr-Thr-Thr-Lys-Phe-Ala-Ala
Description: High affinity angiotensin-converting enzyme (ACE) ligand
Datasheet
Citations
Reviews
Literature

Biological Activity

High affinity angiotensin-converting enzyme (ACE) ligand (Kd = 2.79 nM). Exhibits no significant effect on ACE enzymatic activity up to 500 nM concentration. Potentiates NMDA + D-serine-induced dopamine release from striatal slices in vitro and the striatum in vivo.

Technical Data

M. Wt 932.5
Formula C43H68N10O13
Sequence PPTTTKFAA
Storage Store at -20°C
PubChem ID 122177132
InChI Key VFPBWEDFCUSZRJ-BRCVGTSGSA-N
Smiles [H]N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 2 mg/ml in water

References

References are publications that support the biological activity of the product.

Neasta et al (2016) The novel nonapeptide acein targets angiotensin converting enzyme in the brain and induces dopamine release. Br.J.Pharmacol. 173 1314 PMID: 27027724


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Citations for Acein

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Literature in this Area

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Cardiovascular

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