Acein

Pricing Availability Delivery Time Qty
Cat.No. 6006 - Acein | Pro-Pro-Thr-Thr-Thr-Lys-Phe-Ala-Ala
Description: High affinity angiotensin-converting enzyme (ACE) ligand
Datasheet
Citations
Literature

Biological Activity

High affinity angiotensin-converting enzyme (ACE) ligand (Kd = 2.79 nM). Exhibits no significant effect on ACE enzymatic activity up to 500 nM concentration. Potentiates NMDA + D-serine-induced dopamine release from striatal slices in vitro and the striatum in vivo.

Technical Data

M. Wt 932.5
Formula C43H68N10O13
Sequence PPTTTKFAA
Storage Store at -20°C
PubChem ID 122177132
InChI Key VFPBWEDFCUSZRJ-BRCVGTSGSA-N
Smiles [H]N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 2 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 932.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.07 mL 5.36 mL 10.72 mL
5 mM 0.21 mL 1.07 mL 2.14 mL
10 mM 0.11 mL 0.54 mL 1.07 mL
50 mM 0.02 mL 0.11 mL 0.21 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Neasta et al (2016) The novel nonapeptide acein targets angiotensin converting enzyme in the brain and induces dopamine release. Br.J.Pharmacol. 173 1314 PMID: 7027724


If you know of a relevant reference for Acein, please let us know.

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Keywords: Acein, supplier, High, affinity, angiotensin, converting, enzymes, ACE, ligands, Angiotensin-Converting, Enzyme, Tocris Bioscience

Citations for Acein

Citations are publications that use Tocris products.

Currently there are no citations for Acein. Do you know of a great paper that uses Acein from Tocris? If so please let us know.

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Reviews

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Literature in this Area

Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure

Pathways for Acein

Protocols

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