Discontinued Product

Acein (Cat. No. 6006) has been withdrawn from sale for commercial reasons.
Description: High affinity angiotensin-converting enzyme (ACE) ligand

Biological Activity for Acein

Acein is a high affinity angiotensin-converting enzyme (ACE) ligand (Kd = 2.79 nM). Exhibits no significant effect on ACE enzymatic activity up to 500 nM concentration. Potentiates NMDA + D-serine-induced dopamine release from striatal slices in vitro and the striatum in vivo.

Technical Data for Acein

M. Wt 932.5
Formula C43H68N10O13
Storage Store at -20°C
PubChem ID 122177132
Smiles [H]N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for Acein

References are publications that support the biological activity of the product.

Neasta et al (2016) The novel nonapeptide acein targets angiotensin converting enzyme in the brain and induces DA release. Br.J.Pharmacol. 173 1314 PMID: 27027724

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Keywords: Acein, Acein supplier, High, affinity, angiotensin, converting, enzymes, ACE, ligands, Angiotensin-Converting, Enzyme, 6006, Tocris Bioscience

Citations for Acein

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Currently there are no citations for Acein.

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