GABA receptor agonist and modulator of glutamatergic systems. Reduces alcohol consumption in animal models of alcohol addiction.
Deuterated analog also available.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 200.24. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||9.99 mL||49.94 mL||99.88 mL|
|2.5 mM||2 mL||9.99 mL||19.98 mL|
|5 mM||1 mL||4.99 mL||9.99 mL|
|25 mM||0.2 mL||1 mL||2 mL|
References are publications that support the biological activity of the product.
Spanagel et al (1996) Acamprosate and alcohol: I. Effects on alcohol intake following alcohol deprivation in the rat. Eur.J.Pharmacol. 305 39 PMID: 8813529
Berton et al (1998) Acamprosate enhances N-MthD.-aspartate receptor-mediated neurotransmission but inhibits presynaptic GABA(B) receptors in nucleus accumbens neurons. Alcohol Clin.Exp.Res. 22 183 PMID: 9514305
Popp and Lovinger (2000) Interaction of acamprosate with ethanol and spermine on NMDA receptors in primary cultured neurons. Eur.J.Pharmacol. 394 221 PMID: 10771287
If you know of a relevant reference for Acamprosate calcium, please let us know.
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Keywords: Acamprosate calcium, Acamprosate calcium supplier, GABA, agonists, receptors, glutamate, modulators, metabotropic, mGlu, mGluR, ionotropic, systems, glutamatergics, Calcium, acetylhomotaurinate, Miscellaneous, Glutamate, 3618, Tocris Bioscience
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.