Acamprosate calcium

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Cat.No. 3618 - Acamprosate calcium | C5H10NO4S.½Ca | CAS No. 77337-73-6
Description: GABA agonist; also glutamatergic modulator
Alternative Names: Calcium acetylhomotaurinate
Chemical Name: 3-(Acetylamino)-1-propanesulfonic acid hemicalcium salt
Datasheet
Citations
Reviews
Literature

Biological Activity

GABA receptor agonist and modulator of glutamatergic systems. Reduces alcohol consumption in animal models of alcohol addiction.

Deuterated analog also available.

Technical Data

M. Wt 200.24
Formula C5H10NO4S.½ Ca
Storage Desiccate at RT
CAS Number 77337-73-6
PubChem ID 155434
InChI Key BUVGWDNTAWHSKI-UHFFFAOYSA-L
Smiles CC(=O)NCCCS(=O)(=O)[O-].CC(=O)NCCCS(=O)(=O)[O-].[Ca+2]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 10.01 50

Preparing Stock Solutions

The following data is based on the product molecular weight 200.24. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 9.99 mL 49.94 mL 99.88 mL
2.5 mM 2 mL 9.99 mL 19.98 mL
5 mM 1 mL 4.99 mL 9.99 mL
25 mM 0.2 mL 1 mL 2 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Spanagel et al (1996) Acamprosate and alcohol: I. Effects on alcohol intake following alcohol deprivation in the rat. Eur.J.Pharmacol. 305 39 PMID: 8813529

Berton et al (1998) Acamprosate enhances N-MthD.-aspartate receptor-mediated neurotransmission but inhibits presynaptic GABA(B) receptors in nucleus accumbens neurons. Alcohol Clin.Exp.Res. 22 183 PMID: 9514305

Popp and Lovinger (2000) Interaction of acampr. with ethanol and spermine on NMDA receptors in primary cultured neurons. Eur.J.Pharmacol. 394 221 PMID: 10771287


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Keywords: Acamprosate calcium, Acamprosate calcium supplier, GABA, agonists, receptors, glutamate, modulators, metabotropic, mGlu, mGluR, ionotropic, systems, glutamatergics, Calcium, acetylhomotaurinate, Miscellaneous, Glutamate, 3618, Tocris Bioscience

Citations for Acamprosate calcium

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


GABA Receptors

GABA Receptors Scientific Review

Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.