GABA receptor agonist and modulator of glutamatergic systems. Reduces alcohol consumption in animal models of alcohol addiction.
Deuterated analog also available.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 200.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||9.99 mL||49.94 mL||99.88 mL|
|2.5 mM||2 mL||9.99 mL||19.98 mL|
|5 mM||1 mL||4.99 mL||9.99 mL|
|25 mM||0.2 mL||1 mL||2 mL|
References are publications that support the biological activity of the product.
Spanagel et al (1996) Acamprosate and alcohol: I. Effects on alcohol intake following alcohol deprivation in the rat. Eur.J.Pharmacol. 305 39 PMID: 8813529
Berton et al (1998) Acamprosate enhances N-methyl-D-aspartate receptor-mediated neurotransmission but inhibits presynaptic GABA(B) receptors in nucleus accumbens neurons. Alcohol Clin.Exp.Res. 22 183 PMID: 9514305
Popp and Lovinger (2000) Interaction of acamprosate with ethanol and spermine on NMDA receptors in primary cultured neurons. Eur.J.Pharmacol. 394 221 PMID: 10771287
If you know of a relevant reference for Acamprosate calcium, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Acamprosate calcium, Acamprosate calcium supplier, GABA, agonists, receptors, glutamate, modulators, metabotropic, mGlu, mGluR, ionotropic, systems, glutamatergics, Calcium, acetylhomotaurinate, GABAA, Receptors, GABAA-rho, Miscellaneous, Glutamate, GABAB, 3618, Tocris Bioscience
Citations for Acamprosate calcium
Citations are publications that use Tocris products.
Currently there are no citations for Acamprosate calcium. Do you know of a great paper that uses Acamprosate calcium from Tocris? Please let us know.
Reviews for Acamprosate calcium
There are currently no reviews for this product. Be the first to review Acamprosate calcium and earn rewards!
Have you used Acamprosate calcium?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.