Ac-RYYRIK-NH2

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Cat.No. 1239 - Ac-RYYRIK-NH2 | Ac-Arg-Tyr-Tyr-Arg-Ile-Lys-NH2 | CAS No. 200959-48-4
Description: High affinity NOP ligand
Datasheet
Citations
Literature

Biological Activity

High affinity ligand for the NOP site (Ki = 1.5 nM). Antagonizes nociceptin-stimulated GTP binding in rat brain and the chronotropic effect of nociceptin on rat cardiomyocytes. However, displays potent agonist properties in vivo, inhibiting locomotor activity in mice.

Technical Data

M. Wt 939.12
Formula C44H70N14O9
Sequence RYYRIK

(Modifications: Arg-1 = N-terminal Ac, Lys-6 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 200959-48-4
PubChem ID 9963005
InChI Key WBBBVZGQADABSU-RERZDIOCSA-N
Smiles CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O)C(=O)N[C@@H](CCCCN)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 939.12. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.06 mL 5.32 mL 10.65 mL
5 mM 0.21 mL 1.06 mL 2.13 mL
10 mM 0.11 mL 0.53 mL 1.06 mL
50 mM 0.02 mL 0.11 mL 0.21 mL

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Product Datasheets

Certificate of Analysis is currently unavailable
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Safety Datasheet

References

References are publications that support the products' biological activity.

Berger et al (1999) Antagonism by acetyl-RYYRIK-NH2 of G protein activation in rat brain preparations and of chronotropic effect on rat cardiomyocytes evoked by nociceptin/orphanin FQ. Br.J.Pharmacol. 126 555 PMID: 10188961

Berger et al (1999) Acetyl-RYYRIK-NH2, a nociceptin/orphanin FQ (noc/OFQ) receptor ligand, exhibits properties of an antagonist and agonist as well. Regul.Pept. 80 122 PMID: 10998548

Dooley et al (1997) Binding and in vitro activities of peptides with high affinity for the nociceptin/orphanin FQ receptor, ORL1. J.Pharmacol.Exp.Ther. 283 735 PMID: 9353393


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Keywords: Ac-RYYRIK-NH2, supplier, High, affinity, NOP, ligands, Nociceptin, Receptors, ORL1, OP4, Opioid, NOP, Receptors, NOP, Receptors, Tocris Bioscience

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