Discontinued Product

Ac-LEHD-AFC (Cat. No. 1575) has been withdrawn from sale for commercial reasons.
Description: Fluorogenic caspase substrate
Chemical Name: N-Acetyl-Leu-Glu-His-Asp-(7-amino-4-trifluoromethylcoumarin)
Literature (5)

Biological Activity for Ac-LEHD-AFC

Fluorogenic caspase substrate. Analog of the caspase-9 substrate, LEHD-AFC.

Technical Data for Ac-LEHD-AFC

M. Wt 765.7
Formula C33H38F3N7O11
Sequence LEHD

(Modifications: Leu-1 = N-Ac-Leu, Asp-4 = Asp-(7-amino-4-trifluoromethylcoumarin))

Storage Desiccate at -20°C
CAS Number 210345-03-2
PubChem ID 25108576
Smiles CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(O)=O)C(=O)NC1=CC=C2C(OC(=O)C=C2C(F)(F)F)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Ac-LEHD-AFC

Certificate of Analysis / Product Datasheet
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References for Ac-LEHD-AFC

References are publications that support the biological activity of the product.

Ito et al (1999) Possible involvement of cytochrome c release and sequential activation of caspases in ceramide-induced apoptosis in SK-N-MC cells. Biochim.Biophys.Acta 1452 263 PMID: 10590315

Moriya et al (2000) Mechanism of nitric oxide-induced apoptosis in human neuroblastoma SH-SY5Y cells. FEBS Lett. 484 253 PMID: 11078888

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Keywords: Ac-LEHD-AFC, Ac-LEHD-AFC supplier, Fluorogenic, caspases, Proteinases, Proteases, Caspases, 1575, Tocris Bioscience

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