Discontinued Product

Ac-IEPD-AFC (Cat. No. 1576) has been withdrawn from sale for commercial reasons.
Description: Fluorogenic granzyme B substrate
Chemical Name: N-Acetyl-Ile-Glu-Pro-Asp-(7-amino-4-trifluoromethylcoumarin)
Literature (5)

Biological Activity for Ac-IEPD-AFC

Peptide sequence shown to be preferred recognition motif for the serine protease granzyme B. Fluorogenic substrate.

Technical Data for Ac-IEPD-AFC

M. Wt 725.67
Formula C32H38F3N5O11
Sequence IEPD

(Modifications: Ile-1 = N-Ac-Ile, Asp-4 = Asp-(7-amino-4-trifluoromethylcoumarin))

Storage Desiccate at -20°C
CAS Number 1135417-31-0
PubChem ID 25108575
Smiles CC[C@H](C)[C@H](NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)NC1=CC=C2C(OC(=O)C=C2C(F)(F)F)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Ac-IEPD-AFC

Certificate of Analysis is currently unavailable on-line.
Please contact Customer Service

References for Ac-IEPD-AFC

References are publications that support the biological activity of the product.

Thornberry et al (1997) A combinatorial approach defines specificities of members of the caspase family and granzyme B. J.Biol.Chem. 272 17907 PMID: 9218414

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Keywords: Ac-IEPD-AFC, Ac-IEPD-AFC supplier, Fluorogenic, granzyme, B, Caspases, Proteinases, Proteases, 1576, Tocris Bioscience

Citations for Ac-IEPD-AFC

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Currently there are no citations for Ac-IEPD-AFC.

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