Discontinued ProductUnfortunately Ac-DEVD-AFC (Cat. No. 1573) has been withdrawn from sale for commercial reasons.
Fluorogenic caspase substrate. Analog of the caspase-3-like substrate, DEVD-AFC.
(Modifications: Asp-1 = N-Ac-Asp, Asp-4 = Asp-(7-amino-4-trifluoromethylcoumarin))
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Preparing Stock Solutions
The following data is based on the product molecular weight 729.62. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.37 mL||6.85 mL||13.71 mL|
|5 mM||0.27 mL||1.37 mL||2.74 mL|
|10 mM||0.14 mL||0.69 mL||1.37 mL|
|50 mM||0.03 mL||0.14 mL||0.27 mL|
References are publications that support the products' biological activity.
Jones et al (1998) Fas-mediated apoptosis in mouse hepatocytes involves the processing and activation of caspases. Hepatology 27 1632 PMID: 9620337
Martins et al (1997) Comparison of caspase activation and subcellular localization in HL-60 and K562 cells undergoing etoposide-induced apoptosis. Blood 90 4283 PMID: 9373239
Moriya et al (2000) Mechanism of nitric oxide-induced apoptosis in human neuroblastoma SH-SY5Y cells. FEBS Lett. 484 253 PMID: 11078888
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Keywords: Ac-DEVD-AFC, supplier, Fluorogenic, caspases, Proteinases, Proteases, Caspases, Caspases, Tocris Bioscience
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