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Discontinued ProductAc-DEVD-AFC (Cat. No. 1573) has been withdrawn from sale for commercial reasons.
Biological Activity for Ac-DEVD-AFC
Fluorogenic caspase substrate. Analog of the caspase-3-like substrate, DEVD-AFC.
Technical Data for Ac-DEVD-AFC
(Modifications: Asp-1 = N-Ac-Asp, Asp-4 = Asp-(7-amino-4-trifluoromethylcoumarin))
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References for Ac-DEVD-AFC
References are publications that support the biological activity of the product.
Jones et al (1998) Fas-mediated apoptosis in mouse hepatocytes involves the processing and activation of caspases. Hepatology 27 1632 PMID: 9620337
Martins et al (1997) Comparison of caspase activation and subcellular localization in HL-60 and K562 cells undergoing etoposide-induced apoptosis. Blood 90 4283 PMID: 9373239
Moriya et al (2000) Mechanism of nitric oxide-induced apoptosis in human neuroblastoma SH-SY5Y cells. FEBS Lett. 484 253 PMID: 11078888
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Keywords: Ac-DEVD-AFC, Ac-DEVD-AFC supplier, Fluorogenic, caspases, Proteinases, Proteases, Caspases, 1573, Tocris Bioscience
Citations for Ac-DEVD-AFC
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Currently there are no citations for Ac-DEVD-AFC.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cell Cycle and DNA Damage Research Product Guide
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There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.