ABT

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Cat.No. 5038 - ABT | C6H6N4 | CAS No. 1614-12-6
Description: Cytochrome P450 inhibitor; inhibits 20-HETE synthesis
Chemical Name: 1H-Benzotriazol-1-amine
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Cytochrome P450 inhibitor. Inhibits synthesis of the eicosanoid 20-hydroxyeicosatetraenoic acid (20-HETE). Reduces intimal hyperplasia and vascular remodeling following endothelial injury in rat carotid arteries.

Technical Data

M. Wt 134.14
Formula C6H6N4
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 1614-12-6
PubChem ID 1367
InChI Key JCXKHYLLVKZPKE-UHFFFAOYSA-N
Smiles NN2C1=CC=CC=C1N=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 13.41 100
water 13.41 100

Preparing Stock Solutions

The following data is based on the product molecular weight 134.14. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 7.45 mL 37.27 mL 74.55 mL
5 mM 1.49 mL 7.45 mL 14.91 mL
10 mM 0.75 mL 3.73 mL 7.45 mL
50 mM 0.15 mL 0.75 mL 1.49 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Mathews et al (1985) Inactivation of rabbit pulmonary cytochrome P-450 in microsomes and isolated perfused lungs by the suicide substrate 1-aminobenzotriazole. J.Pharmacol.Exp.Ther. 235 186 PMID: 4045721

Orozco et al (2013) 20-hydroxyeicosatetraenoic acid inhibition attenuates balloon injury-induced neointima formation and vascular remodeling in rat carotid arteries. J.Pharmacol.Exp.Ther. 346 67 PMID: 23658377


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Keywords: ABT, ABT supplier, cytochrome, p450, inhibitors, inhibits, cyp450, synthesis, 20-HETE, Cytochrome, P450, 5038, Tocris Bioscience

1 Citation for ABT

Citations are publications that use Tocris products. Selected citations for ABT include:

Zhu and Gomez (2012) Further evidence for the role of IP 3R 1 in regulating subsynaptic gene expression and neuromuscular transmission. Pharmacol Res Perspect 6 65 PMID: 22418950


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Reviews for ABT

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Literature in this Area

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