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Cat.No. 5038 - ABT | C6H6N4 | CAS No. 1614-12-6
Description: Cytochrome P450 inhibitor; inhibits 20-HETE synthesis
Chemical Name: 1H-Benzotriazol-1-amine
Purity: ≥98% (HPLC)
Citations (1)

Biological Activity for ABT

ABT is a cytochrome P450 inhibitor. Inhibits synthesis of the eicosanoid 20-hydroxyeicosatetraenoic acid (20-HETE). Reduces intimal hyperplasia and vascular remodeling following endothelial injury in rat carotid arteries.

Technical Data for ABT

M. Wt 134.14
Formula C6H6N4
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 1614-12-6
PubChem ID 1367
Smiles NN2C1=CC=CC=C1N=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ABT

Solvent Max Conc. mg/mL Max Conc. mM
water 13.41 100
DMSO 13.41 100

Preparing Stock Solutions for ABT

The following data is based on the product molecular weight 134.14. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 7.45 mL 37.27 mL 74.55 mL
5 mM 1.49 mL 7.45 mL 14.91 mL
10 mM 0.75 mL 3.73 mL 7.45 mL
50 mM 0.15 mL 0.75 mL 1.49 mL

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References for ABT

References are publications that support the biological activity of the product.

Mathews et al (1985) Inactivation of rabbit pulmonary cytochrome P-450 in microsomes and isolated perfused lungs by the suicide substrate 1-aminobenzotriazole. J.Pharmacol.Exp.Ther. 235 186 PMID: 4045721

Orozco et al (2013) 20-hydroxyeicosatetraenoic acid inhibition attenuates balloon injury-induced neointima formation and vascular remodeling in rat carotid arteries. J.Pharmacol.Exp.Ther. 346 67 PMID: 23658377

If you know of a relevant reference for ABT, please let us know.

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Keywords: ABT, ABT supplier, cytochrome, p450, inhibitors, inhibits, cyp450, synthesis, 20-HETE, Cytochrome, P450, 5038, Tocris Bioscience

1 Citation for ABT

Citations are publications that use Tocris products. Selected citations for ABT include:

Zhu and Gomez (2012) Further evidence for the role of IP 3R 1 in regulating subsynaptic gene expression and neuromuscular transmission. Pharmacol Res Perspect 6 65 PMID: 22418950

Do you know of a great paper that uses ABT from Tocris? Please let us know.

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