ABT 751

Discontinued Product

ABT 751 (Cat. No. 4138) has been withdrawn from sale for commercial reasons.
Description: Inhibitor of microtubule polymerization; antimitotic and antitumor
Chemical Name: N-[2-[(4-Hydroxyphenyl)amino]-3-pyridinyl]-4-methoxybenzenesulfonamide
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for ABT 751

ABT 751 is an antimitotic agent, inhibits microtubule polymerization. Binds to β-tubulin on the colchine site; blocks cell cycle at G2M phase and induces apoptosis. Exhibits antitumor activity. Also displays activity in cell lines resistant to vincristine, doxorubicin and cisplatin. Orally bioavailable.

Technical Data for ABT 751

M. Wt 371.41
Formula C18H17N3O4S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 141430-65-1
PubChem ID 3035714
Smiles OC(C=C2)=CC=C2NC1=NC=CC=C1NS(C3=CC=C(OC)C=C3)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for ABT 751

References are publications that support the biological activity of the product.

Hande et al (2006) The pharmacokinetics and safety of ABT-751, a novel, orally bioavailable sulfonamide antimitotic agent: results of a phase 1 study. Clin.Cancer Res. 12 2834 PMID: 16675578

Keywords: ABT 751, ABT 751 supplier, ABT751, microtubule, antitumor, antimitotic, beta, tubulin, b-tubulin, blocks, cell, cycle, G2M, proapoptotic, Microtubules, Cell, Cycle, Inhibitors, 4138, Tocris Bioscience

Citations for ABT 751

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Currently there are no citations for ABT 751.

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Literature in this Area

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Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 170 products, including research tools for:

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