ABS 205

Discontinued Product

Unfortunately ABS 205 (Cat. No. 2721) has been withdrawn from sale for commercial reasons.
Cat.No. 2721 - ABS 205 | C8H12O2 | CAS No. 24102-11-2
Description: Upregulates NCAM expression. Valproic acid (Cat. No. 2815) derivative
Alternative Names: 4-yn-VPA
Chemical Name: 2-Propyl-4-pentynoic acid
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Citations
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Literature

Biological Activity

Orally active valproic acid (Cat No. 2815) derivative that exhibits teratogenic and neuroprotective activity. Upregulates neural cell adhesion molecule (NCAM) expression, activates PPARδ (IC50 = 0.6 mM) and increases Hoxa1 expression in rat embryos. Antiproliferative; induces G1 cell cycle arrest in C6 glioma cells (IC50 ~ 2 mM).

Technical Data

M. Wt 140.18
Formula C8H12O2
Storage Store at +4°C
CAS Number 24102-11-2
Smiles CCCC(C(O)=O)CC#C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 140.18. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 7.13 mL 35.67 mL 71.34 mL
5 mM 1.43 mL 7.13 mL 14.27 mL
10 mM 0.71 mL 3.57 mL 7.13 mL
50 mM 0.14 mL 0.71 mL 1.43 mL

Molarity Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Bacon et al (1998) Cell proliferation, migration and CAM-dependent neurite outgrowth as developmental in vitro endpoints for screening teratogenic potential: application to valproic acid and related analogues of varying potency. Toxicol.In Vitro 12 101 PMID: 20654391

Lampen et al (2005) Modulation of peroxisome proliferator-activated receptor δ activity affects neural cell adhesion molecule and polysialyltransferase ST8SiaIV induction by teratogenic valproic acid analogs in F9 cell differentiation. Mol.Pharmacol. 68 193 PMID: 15829700

Stodgell et al (2006) Induction of the homeotic gene Hoxa1 through valproic acid's teratogenic mechanism of action. Neurotoxicol.Teratol. 28 617 PMID: 16989981

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Citations for ABS 205

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