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Orally active valproic acid (Cat No. 2815) derivative that exhibits teratogenic and neuroprotective activity. Upregulates neural cell adhesion molecule (NCAM) expression, activates PPARδ (IC50 = 0.6 mM) and increases Hoxa1 expression in rat embryos. Antiproliferative; induces G1 cell cycle arrest in C6 glioma cells (IC50 ~ 2 mM).
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The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Bacon et al (1998) Cell proliferation, migration and CAM-dependent neurite outgrowth as developmental in vitro endpoints for screening teratogenic potential: application to valproic acid and related analogues of varying potency. Toxicol.In Vitro 12 101 PMID: 20654391
Lampen et al (2005) Modulation of peroxisome proliferator-activated receptor δ activity affects neural cell adhesion molecule and polysialyltransferase ST8SiaIV induction by teratogenic valproic acid analogs in F9 cell differentiation. Mol.Pharmacol. 68 193 PMID: 15829700
Stodgell et al (2006) Induction of the homeotic gene Hoxa1 through valproic acid's teratogenic mechanism of action. Neurotoxicol.Teratol. 28 617 PMID: 16989981
Keywords: ABS 205, ABS 205 supplier, Upregulates, NCAM, expression, Adhesion, Molecules, ABS205, 4-yn-VPA, Cell, 2721, Tocris Bioscience
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