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Cat.No. 5113 - AbK | C11H20N4O4 | CAS No. 1253643-88-7
Description: Photo-crosslinking probe
Chemical Name: N6-[[2-(3-Methyl-3H-diazirin-3-yl)ethoxy]carbonyl]-L-lysine
Purity: ≥98% (HPLC)

Biological Activity

Unnatural amino acid. Acts as a UV light-activated photo-crosslinking probe when incorporated into proteins by pyrrolysyl tRNA synthetase/tRNACUA pairs.

Technical Data

M. Wt 272.3
Formula C11H20N4O4.CF3CO2H
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1253643-88-7
PubChem ID 66825403
Smiles N[C@H](C(O)=O)CCCCNC(OCCC1(C)N=N1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 2.72 10mM with gentle warming
1eq. HCl 27.23 100

Preparing Stock Solutions

The following data is based on the product molecular weight 272.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.67 mL 18.36 mL 36.72 mL
5 mM 0.73 mL 3.67 mL 7.34 mL
10 mM 0.37 mL 1.84 mL 3.67 mL
50 mM 0.07 mL 0.37 mL 0.73 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Ai et al (2011) Probing protein-protein interactions with a genetically encoded photo-crosslinking amino acid. Chembiochem 12 1854 PMID: 21678540

Chatterjee et al (2013) Efficient viral delivery system for unnatural amino acid mutagenesis in mammalian cells. Proc.Natl.Acad.Sci.U.S.A. 110 11803 PMID: 23818609

Lowder et al (2011) Visualizing protein partnerships in living cells and organisms. Curr.Opin.Cell Biol. 15 781 PMID: 22104179

Kleiner et al (2018) A chemical proteomics approach to reveal direct protein-protein interactions in living cells. Cell Chem.Biol. 25 110 PMID: 29104064

If you know of a relevant reference for AbK, please let us know.

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Keywords: AbK, supplier, photo-crosslinking, amino, acids, UV, light, tRNA, synthetase, pairs, reagents, photocrosslinking, Biochemicals, and, Molecular, Biology, Biochemicals, and, Molecular, Biology, Tocris Bioscience

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