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Description: Photo-crosslinking probe; unnatural amino acid
Chemical Name: N6-[[2-(3-Methyl-3H-diazirin-3-yl)ethoxy]carbonyl]-L-lysine
Purity: ≥98% (HPLC)
Citations (1)

Biological Activity for AbK

AbK is an unnatural amino acid. Acts as a UV light-activated (369 nm) photocrosslinking probe when incorporated into proteins by pyrrolysyl tRNA synthetase/tRNACUA pairs.

Technical Data for AbK

M. Wt 272.3
Formula C11H20N4O4.CF3CO2H
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1253643-88-7
PubChem ID 66825403
Smiles N[C@H](C(O)=O)CCCCNC(OCCC1(C)N=N1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AbK

Solvent Max Conc. mg/mL Max Conc. mM
water 2.72 10 with gentle warming
1eq. HCl 27.23 100

Preparing Stock Solutions for AbK

The following data is based on the product molecular weight 272.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.67 mL 18.36 mL 36.72 mL
5 mM 0.73 mL 3.67 mL 7.34 mL
10 mM 0.37 mL 1.84 mL 3.67 mL
50 mM 0.07 mL 0.37 mL 0.73 mL

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References for AbK

References are publications that support the biological activity of the product.

Ai et al (2011) Probing protein-protein interactions with a genetically encoded photo-crosslinking amino acid. Chembiochem 12 1854 PMID: 21678540

Chatterjee et al (2013) Efficient viral delivery system for unnatural amino acid mutagenesis in mammalian cells. Proc.Natl.Acad.Sci.U.S.A. 110 11803 PMID: 23818609

Lowder et al (2011) Visualizing protein partnerships in living cells and organisms. Curr.Opin.Cell Biol. 15 781 PMID: 22104179

Kleiner et al (2018) A chemical proteomics approach to reveal direct protein-protein interactions in living cells. Cell Chem.Biol. 25 110 PMID: 29104064

If you know of a relevant reference for AbK, please let us know.

Keywords: AbK, AbK supplier, photo-crosslinking, amino, acids, UV, light, tRNA, synthetase, pairs, reagents, photocrosslinking, unnatural, acid, UAA, Biochemicals, and, Molecular, Biology, Unnatural, Amino, Acids, Photoactivatable, cross-linking, probes, 5113, Tocris Bioscience

1 Citation for AbK

Citations are publications that use Tocris products. Selected citations for AbK include:

Syed et al (2019) Expanding the Zebrafish Genetic Code through Site-Specific Introduction of Azido-lysine, Bicyclononyne-lysine, and Diazirine-lysine. Int J Mol Sci 20 PMID: 31130675

Do you know of a great paper that uses AbK from Tocris? Please let us know.

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