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Unnatural amino acid. Acts as a UV light-activated photo-crosslinking probe when incorporated into proteins by pyrrolysyl tRNA synthetase/tRNACUA pairs.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|water||2.72||10 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 272.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.67 mL||18.36 mL||36.72 mL|
|5 mM||0.73 mL||3.67 mL||7.34 mL|
|10 mM||0.37 mL||1.84 mL||3.67 mL|
|50 mM||0.07 mL||0.37 mL||0.73 mL|
References are publications that support the biological activity of the product.
Ai et al (2011) Probing protein-protein interactions with a genetically encoded photo-crosslinking amino acid. Chembiochem 12 1854 PMID: 21678540
Chatterjee et al (2013) Efficient viral delivery system for unnatural amino acid mutagenesis in mammalian cells. Proc.Natl.Acad.Sci.U.S.A. 110 11803 PMID: 23818609
Lowder et al (2011) Visualizing protein partnerships in living cells and organisms. Curr.Opin.Cell Biol. 15 781 PMID: 22104179
Kleiner et al (2018) A chemical proteomics approach to reveal direct protein-protein interactions in living cells. Cell Chem.Biol. 25 110 PMID: 29104064
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Keywords: AbK, AbK supplier, photo-crosslinking, amino, acids, UV, light, tRNA, synthetase, pairs, reagents, photocrosslinking, unnatural, acid, UAA, Biochemicals, and, Molecular, Biology, Unnatural, Amino, Acids, Photoactivatable, cross-linking, probes, 5113, Tocris Bioscience
1 Citation for AbK
Citations are publications that use Tocris products. Selected citations for AbK include:
Syed et al (2019) Expanding the Zebrafish Genetic Code through Site-Specific Introduction of Azido-lysine, Bicyclononyne-lysine, and Diazirine-lysine. Int J Mol Sci 20 PMID: 31130675
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