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Abacavir hemisulfate

Cat. No. 4148 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Reverse transcriptase inhibitor; antiretroviral
Chemical Name: (1S,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol hemisulfate
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Abacavir hemisulfate

Abacavir hemisulfate is a competitive reverse transcriptase inhibitor; inhibits HIV replication. Orally active and brain penetrant. Antiretroviral agent.

Licensing Information

Sold for research purposes under agreement from Viiv.

Compound Libraries for Abacavir hemisulfate

Abacavir hemisulfate is also offered as part of the Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Abacavir hemisulfate

M. Wt 335.37
Formula C14H18N6O.½H2SO4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 188062-50-2
PubChem ID 75539558
InChI Key WMHSRBZIJNQHKT-NHMRBCHTSA-N
Smiles OS(O)(=O)=O.NC1=NC(NC2CC2)=C2N=CN(C3C[C@H](CO)C=C3)C2=N1.NC1=NC(NC2CC2)=C2N=CN(C3C[C@H](CO)C=C3)C2=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Abacavir hemisulfate

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 33.54 100
DMSO 16.77 50

Preparing Stock Solutions for Abacavir hemisulfate

The following data is based on the product molecular weight 335.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.98 mL 14.91 mL 29.82 mL
5 mM 0.6 mL 2.98 mL 5.96 mL
10 mM 0.3 mL 1.49 mL 2.98 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

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Product Datasheets for Abacavir hemisulfate

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for Abacavir hemisulfate

References are publications that support the biological activity of the product.

Charneira et al (2012) N-terminal valine adduct from the anti-HIV drug aba. in rat haemoglobin as evidence for aba. metabolism to a reactive aldehyde in vivo. Br.J.Pharmacol. 167 1353 PMID: 22725138

Harrigan et al (2000) Resistance profile of the human immunodeficiency virus type 1 reverse transcriptase inhibitor aba. (1592U89) after monotherapy and combination therapy. CNA2001 Investigative Group. J.Infect.Dis. 181 912 PMID: 10720512

Daluge et al (1997) 1592U89, a novel carbocyclic nucleoside analog with potent, selective anti-human immunodeficiency virus activity. Antimicrob Agents Chemother. 41 1082 PMID: 9145874

If you know of a relevant reference for Abacavir hemisulfate, please let us know.

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Citations for Abacavir hemisulfate

Citations are publications that use Tocris products.

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