Abacavir hemisulfate

Pricing Availability   Qty
Description: Reverse transcriptase inhibitor; antiretroviral
Chemical Name: (1S,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol hemisulfate
Purity: ≥99% (HPLC)
Citations (1)
Literature (1)

Biological Activity for Abacavir hemisulfate

Abacavir hemisulfate is a competitive reverse transcriptase inhibitor; inhibits HIV replication. Orally active and brain penetrant. Antiretroviral agent.

Licensing Information

Sold for research purposes under agreement from Viiv.

Compound Libraries for Abacavir hemisulfate

Abacavir hemisulfate is also offered as part of the Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Abacavir hemisulfate

M. Wt 335.37
Formula C14H18N6O.½H2SO4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 188062-50-2
PubChem ID 75539558
Smiles OS(O)(=O)=O.NC1=NC(NC2CC2)=C2N=CN(C3C[C@H](CO)C=C3)C2=N1.NC1=NC(NC2CC2)=C2N=CN(C3C[C@H](CO)C=C3)C2=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Abacavir hemisulfate

Solvent Max Conc. mg/mL Max Conc. mM
water 33.54 100
DMSO 16.77 50

Preparing Stock Solutions for Abacavir hemisulfate

The following data is based on the product molecular weight 335.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.98 mL 14.91 mL 29.82 mL
5 mM 0.6 mL 2.98 mL 5.96 mL
10 mM 0.3 mL 1.49 mL 2.98 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

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Product Datasheets for Abacavir hemisulfate

References for Abacavir hemisulfate

References are publications that support the biological activity of the product.

Charneira et al (2012) N-terminal valine adduct from the anti-HIV drug aba. in rat haemoglobin as evidence for aba. metabolism to a reactive aldehyde in vivo. Br.J.Pharmacol. 167 1353 PMID: 22725138

Harrigan et al (2000) Resistance profile of the human immunodeficiency virus type 1 reverse transcriptase inhibitor aba. (1592U89) after monotherapy and combination therapy. CNA2001 Investigative Group. J.Infect.Dis. 181 912 PMID: 10720512

Daluge et al (1997) 1592U89, a novel carbocyclic nucleoside analog with potent, selective anti-human immunodeficiency virus activity. Antimicrob Agents Chemother. 41 1082 PMID: 9145874

If you know of a relevant reference for Abacavir hemisulfate, please let us know.

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1 Citation for Abacavir hemisulfate

Citations are publications that use Tocris products. Selected citations for Abacavir hemisulfate include:

Roshanak et al (2019) Golgi localized β1-adrenergic receptors stimulate Golgi PI4P hydrolysis by PLCε to regulate cardiac hypertrophy. Elife 8 PMID: 31433293

Do you know of a great paper that uses Abacavir hemisulfate from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Epigenetics Scientific Review

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.