Abacavir hemisulfate

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Cat.No. 4148 - Abacavir hemisulfate | C14H18N6O.1/2H2SO4 | CAS No. 188062-50-2
Description: Reverse transcriptase inhibitor; antiretroviral
Chemical Name: (1S,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol hemisulfate
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Competitive reverse transcriptase inhibitor; inhibits HIV replication. Orally active and brain penetrant. Antiretroviral agent.

Licensing Information

Sold for research purposes under agreement from Viiv.

Compound Libraries

Abacavir hemisulfate is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 335.37
Formula C14H18N6O.½H2SO4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 188062-50-2
PubChem ID 75539558
InChI Key WMHSRBZIJNQHKT-NHMRBCHTSA-N
Smiles OS(O)(=O)=O.NC1=NC(NC2CC2)=C2N=CN(C3C[C@H](CO)C=C3)C2=N1.NC1=NC(NC2CC2)=C2N=CN(C3C[C@H](CO)C=C3)C2=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 16.77 50
water 33.54 100

Preparing Stock Solutions

The following data is based on the product molecular weight 335.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.98 mL 14.91 mL 29.82 mL
5 mM 0.6 mL 2.98 mL 5.96 mL
10 mM 0.3 mL 1.49 mL 2.98 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

Molarity Calculator

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Reconstitution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Charneira et al (2012) N-terminal valine adduct from the anti-HIV drug abacavir in rat haemoglobin as evidence for abacavir metabolism to a reactive aldehyde in vivo. Br.J.Pharmacol. 167 1353 PMID: 22725138

Harrigan et al (2000) Resistance profile of the human immunodeficiency virus type 1 reverse transcriptase inhibitor abacavir (1592U89) after monotherapy and combination therapy. CNA2001 Investigative Group. J.Infect.Dis. 181 912 PMID: 10720512

Daluge et al (1997) 1592U89, a novel carbocyclic nucleoside analog with potent, selective anti-human immunodeficiency virus activity. Antimicrob Agents Chemother. 41 1082 PMID: 9145874


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Citations for Abacavir hemisulfate

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