AAQ chloride

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Description: Photoswitchable Kv channel blocker
Chemical Name: N,N,N-Triethyl-2-oxo-2-[[4-[2-[4-[(1-oxo-2-propen-1-yl)amino]phenyl]diazenyl]phenylamino]ethanaminium chloride
Purity: ≥98% (HPLC)
Citations (1)

Biological Activity for AAQ chloride

AAQ chloride is a photoswitchable Kv channel blocker (IC50 values are 2 and 64 μM at 500 nm and 380 nm respectively). Switches conformation from cis to trans at 500 nm and trans to cis at 380 nm. Exhibits minimal activity at Nav1.2 and L-type Ca2+ channels. Stimulates action potential firing of hippocampal neurons in vitro at 500 nm and restores visual responsiveness in blind mice at 380 nm.

Licensing Information

Sold under license from Photoswitch Biosciences, Inc.

Technical Data for AAQ chloride

M. Wt 443.97
Formula C23H30ClN5O2
Storage Store at -20°C
Purity ≥98% (HPLC)
PubChem ID 91826090
Smiles O=C(C=C)NC(C=C2)=CC=C2/N=N/C1=CC=C(NC(C[N+](CC)(CC)CC)=O)C=C1.[Cl-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AAQ chloride

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 8.88 20

Preparing Stock Solutions for AAQ chloride

The following data is based on the product molecular weight 443.97. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 11.26 mL 56.31 mL 112.62 mL
1 mM 2.25 mL 11.26 mL 22.52 mL
2 mM 1.13 mL 5.63 mL 11.26 mL
10 mM 0.23 mL 1.13 mL 2.25 mL

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References for AAQ chloride

References are publications that support the biological activity of the product.

Fortin et al (2008) Photochemical control of endogenous ion channels and cellular excitability. Nat.Methods 5 331 PMID: 18311146

Polosukhina et al (2012) Photochemical restoration of visual responses in blind mice. Neuron 75 271 PMID: 22841312

Banghart et al (2009) Photochromic blockers of voltage-gated potassium channels. Angew.Chem.Int.Ed. 48 9097 PMID: 19882609

If you know of a relevant reference for AAQ chloride, please let us know.

Keywords: AAQ chloride, AAQ chloride supplier, selective, photoswitchable, Kv, potassium, channels, K+, blockers, ligands, Photoswitchable, Ligands, Voltage-Gated, Potassium, Channels, 5462, Tocris Bioscience

1 Citation for AAQ chloride

Citations are publications that use Tocris products. Selected citations for AAQ chloride include:

Nikolaev et al (2022) Development of a quaternary ammonium photoswitchable antagonist of NMDA receptors. Eur J Pharmacol. 938 175448 PMID: 36470444

Do you know of a great paper that uses AAQ chloride from Tocris? Please let us know.

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