A12B4C3

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Cat.No. 5097 - A12B4C3 | C30H38N4O5 | CAS No. 1005129-80-5
Description: Potent and selective polynucleotide kinase/phosphatase (PNKP) inhibitor
Chemical Name: 4a,7a-Dihydro-2-(1-hydroxyundecyl)-1-[(4-nitrophenyl)amino]-6-phenyl-1H-pyrrolo[3,4-b]pyridine-5,7(2H,6H)-dione
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent and selective polynucleotide kinase/phosphatase (PNKP) inhibitor (IC50 = 60 nM). Displays no effect on calcineurin, protein PP-1 or APTX. Interrupts DNA repair and enhances radiosensitivity of human A549 lung carcinoma and MDA-MB-231 cells.

Compound Libraries

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Technical Data

M. Wt 534.65
Formula C30H38N4O5
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1005129-80-5
PubChem ID 6610064
InChI Key KVHGJAKTBPFFNV-UHFFFAOYSA-N
Smiles O=C2N(C4=CC=CC=C4)C(C1C=CC(C(O)CCCCCCCCCC)N(NC3=CC=C([N+]([O-])=O)C=C3)C12)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 53.47 100

Preparing Stock Solutions

The following data is based on the product molecular weight 534.65. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.87 mL 9.35 mL 18.7 mL
5 mM 0.37 mL 1.87 mL 3.74 mL
10 mM 0.19 mL 0.94 mL 1.87 mL
50 mM 0.04 mL 0.19 mL 0.37 mL

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References

References are publications that support the biological activity of the product.

Freschauf et al (2009) Identification of a small molecule inhibitor of the human DNA repair enzyme polynucleotide kinase/phosphatase. Cancer Res. 69 7739 PMID: 19773431

Freschauf et al (2010) Mechanism of action of an imidopiperidine inhibitor of human polynucleotide kinase/phosphatase. J.Biol.Chem. 285 2351 PMID: 19940137

Schellenberg et al (2011) DNA end processing by polynucleotide kinase/phosphatase. Proc.Natl.Acad.Sci.U.S.A. 108 20855 PMID: 22184240


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Keywords: A12B4C3, A12B4C3 supplier, Potent, selective, polynucleotide, kinases, phosphatases, PKNP, inhibitors, inhibits, DNA, repair, Other, Kinases, 5097, Tocris Bioscience

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