α-Spinasterol

Pricing Availability Delivery Time Qty
Cat.No. 4729 - alpha-Spinasterol | C29H48O | CAS No. 481-18-5
Description: TRPV1 antagonist; active in vivo
Chemical Name: (3β,5α,22E)-Stigmasta-7.22-dien-3-ol
Purity: ≥95% (HPLC)
Datasheet
Citations
Literature

Biological Activity

TRPV1 antagonist (IC50 = 1.4 μM). Reduces capsaicin-mediated Ca2+ influx in vitro; displays antinociceptive and antiedematogenic effects in multiple mouse models of pain. Brain penetrant and orally bioavailable.

Technical Data

M. Wt 412.69
Formula C29H48O
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 481-18-5
PubChem ID 5281331
InChI Key JZVFJDZBLUFKCA-FXIAWGAOSA-N
Smiles C[C@H](/C=C/[C@@H](CC)C(C)C)[C@@]4([H])CC[C@@]3([H])C2=CC[C@@]1([H])C[C@@H](O)CC[C@@](C)1[C@]([H])2CC[C@@]34C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 4.13 10mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 412.69. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.42 mL 12.12 mL 24.23 mL
5 mM 0.48 mL 2.42 mL 4.85 mL
10 mM 0.24 mL 1.21 mL 2.42 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Trevisan et al (2012) Identification of the plant steroid α-spinasterol as a novel transient receptor potential vanilloid 1 antagonist with antinociceptive properties. J.Pharmacol.Exp.Ther. 343 258 PMID: 22837009


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Keywords: alpha-Spinasterol α-Spinasterol antinociceptives TRPV1 blockers antagonists blocks inhibits antiedematogenics in vivo brain penetrant orally bioavailable TRPV

Citations for α-Spinasterol

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Literature in this Area

Pain

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
Pain

Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.

Pathways for α-Spinasterol

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