TRPV1 antagonist (IC50 = 1.4 μM). Reduces capsaicin-mediated Ca2+ influx in vitro; displays antinociceptive and antiedematogenic effects in multiple mouse models of pain. Brain penetrant and orally bioavailable.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|ethanol||4.13||10mM with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 412.69. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.42 mL||12.12 mL||24.23 mL|
|5 mM||0.48 mL||2.42 mL||4.85 mL|
|10 mM||0.24 mL||1.21 mL||2.42 mL|
|50 mM||0.05 mL||0.24 mL||0.48 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Trevisan et al (2012) Identification of the plant steroid α-spinasterol as a novel transient receptor potential vanilloid 1 antagonist with antinociceptive properties. J.Pharmacol.Exp.Ther. 343 258 PMID: 22837009
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Keywords: alpha-Spinasterol α-Spinasterol antinociceptives TRPV1 blockers antagonists blocks inhibits antiedematogenics in vivo brain penetrant orally bioavailable TRPV
Citations for α-Spinasterol
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Literature in this Area
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.