α-Spinasterol

Discontinued Product

α-Spinasterol (Cat. No. 4729) has been withdrawn from sale for commercial reasons.
Description: TRPV1 antagonist; active in vivo
Chemical Name: (3β,5α,22E)-Stigmasta-7.22-dien-3-ol
Purity: ≥95% (HPLC)
Datasheet
Citations
Reviews

Biological Activity for α-Spinasterol

α-Spinasterol is a TRPV1 antagonist (IC50 = 1.4 μM). Reduces capsaicin-mediated Ca2+ influx in vitro; displays antinociceptive and antiedematogenic effects in multiple mouse models of pain. Brain penetrant and orally bioavailable.

Technical Data for α-Spinasterol

M. Wt 412.69
Formula C29H48O
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 481-18-5
PubChem ID 5281331
InChI Key JZVFJDZBLUFKCA-FXIAWGAOSA-N
Smiles C[C@H](/C=C/[C@@H](CC)C(C)C)[C@@]4([H])CC[C@@]3([H])C2=CC[C@@]1([H])C[C@@H](O)CC[C@@](C)1[C@]([H])2CC[C@@]34C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for α-Spinasterol

References for α-Spinasterol

References are publications that support the biological activity of the product.

Trevisan et al (2012) Identification of the plant steroid α-spinasterol as a novel transient receptor potential vanilloid 1 antagonist with antinociceptive properties. J.Pharmacol.Exp.Ther. 343 258 PMID: 22837009

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Citations for α-Spinasterol

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Currently there are no citations for α-Spinasterol.

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