α-Spinasterol

Pricing Availability   Qty
Cat.No. 4729 - alpha-Spinasterol | C29H48O | CAS No. 481-18-5
Description: TRPV1 antagonist; active in vivo
Chemical Name: (3β,5α,22E)-Stigmasta-7.22-dien-3-ol
Purity: ≥95% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

TRPV1 antagonist (IC50 = 1.4 μM). Reduces capsaicin-mediated Ca2+ influx in vitro; displays antinociceptive and antiedematogenic effects in multiple mouse models of pain. Brain penetrant and orally bioavailable.

Technical Data

M. Wt 412.69
Formula C29H48O
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 481-18-5
PubChem ID 5281331
InChI Key JZVFJDZBLUFKCA-FXIAWGAOSA-N
Smiles C[C@H](/C=C/[C@@H](CC)C(C)C)[C@@]4([H])CC[C@@]3([H])C2=CC[C@@]1([H])C[C@@H](O)CC[C@@](C)1[C@]([H])2CC[C@@]34C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 4.13 10 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 412.69. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.23 mL 121.16 mL 242.31 mL
0.5 mM 4.85 mL 24.23 mL 48.46 mL
1 mM 2.42 mL 12.12 mL 24.23 mL
5 mM 0.48 mL 2.42 mL 4.85 mL

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References

References are publications that support the biological activity of the product.

Trevisan et al (2012) Identification of the plant steroid α-spinasterol as a novel transient receptor potential vanilloid 1 antagonist with antinociceptive properties. J.Pharmacol.Exp.Ther. 343 258 PMID: 22837009


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Citations for α-Spinasterol

Citations are publications that use Tocris products.

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Literature in this Area

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