α-Methyl-5-hydroxytryptamine maleate

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Cat.No. 0557 - alpha-Methyl-5-hydroxytryptamine maleate | C11H14N2O.C4H4O4 | CAS No. 97469-12-0
Description: 5-HT2B agonist
Purity: ≥98% (HPLC)
Datasheet
Citations (4)
Reviews
Literature (3)

Biological Activity

5-HT2B receptor selective agonist with pKi values of 8.4, 6.1 and 7.3 at 5-HT2B, 5-HT2A and 5-HT2C receptors respectively.

Technical Data

M. Wt 306.32
Formula C11H14N2O.C4H4O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 97469-12-0
PubChem ID 9922558
InChI Key YQNHFSXRABPJLP-BTJKTKAUSA-N
Smiles OC(=O)\C=C/C(O)=O.CC(N)CC1=CNC2=C1C=C(O)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 10
DMSO 30.63 100

Preparing Stock Solutions

The following data is based on the product molecular weight 306.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.26 mL 16.32 mL 32.65 mL
5 mM 0.65 mL 3.26 mL 6.53 mL
10 mM 0.33 mL 1.63 mL 3.26 mL
50 mM 0.07 mL 0.33 mL 0.65 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Baxter et al (1995) 5-HT2 receptor subtypes: a family re-united? TiPS 16 105 PMID: 7792930

Richardson et al (1985) Identification of serotonin M-receptor sub-types and their specific blockade by a new class of drugs. Nature 316 126 PMID: 3839291

Wilson et al (1990) 5-Hydroxytryptamine3 receptors mediate tachycardia in conscious instrumented dogs. J.Pharmacol.Exp.Ther. 252 683 PMID: 1968974


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4 Citations for α-Methyl-5-hydroxytryptamine maleate

Citations are publications that use Tocris products. Selected citations for α-Methyl-5-hydroxytryptamine maleate include:

Nguyen et al (2019) Potentiation of the glycine response by serotonin on the substantia gelatinosa neurons of the trigeminal subnucleus caudalis in mice. Korean J Physiol Pharmacol 23 271 PMID: 31297011

Majeed et al (2016) Modulatory Action by the Serotonergic System: Behavior and Neurophysiology in Drosophila melanogaster. Neural Plast 2016 7291438 PMID: 26989517

Athilingam et al (2017) Serotonin enhances excitability and gamma frequency temporal integration in mouse prefrontal fast-spiking interneurons. Elife 6 PMID: 29206101

Coulon et al (2011) Activity Modes in Thalamocortical Relay Neurons are Modulated by G(q)/G(11) Family G-proteins - Serotonergic and Glutamatergic Signaling. Front Cell Neurosci 4 132 PMID: 21267426


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Literature in this Area

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