α-Methyl-5-hydroxytryptamine maleate

Pricing Availability Delivery Time Qty
Cat.No. 0557 - alpha-Methyl-5-hydroxytryptamine maleate | C11H14N2O.C4H4O4 | CAS No. 97469-12-0
Description: 5-HT2B agonist
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

5-HT2B receptor selective agonist with pKi values of 8.4, 6.1 and 7.3 at 5-HT2B, 5-HT2A and 5-HT2C receptors respectively.

Compound Libraries

α-Methyl-5-hydroxytryptamine maleate is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 306.32
Formula C11H14N2O.C4H4O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 97469-12-0
PubChem ID 9922558
InChI Key YQNHFSXRABPJLP-BTJKTKAUSA-N
Smiles OC(=O)\C=C/C(O)=O.CC(N)CC1=CNC2=C1C=C(O)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.63 100
water 10

Preparing Stock Solutions

The following data is based on the product molecular weight 306.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.26 mL 16.32 mL 32.65 mL
5 mM 0.65 mL 3.26 mL 6.53 mL
10 mM 0.33 mL 1.63 mL 3.26 mL
50 mM 0.07 mL 0.33 mL 0.65 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Baxter et al (1995) 5-HT2 receptor subtypes: a family re-united? TiPS 16 105 PMID: 7792930

Richardson et al (1985) Identification of serotonin M-receptor sub-types and their specific blockade by a new class of drugs. Nature 316 126 PMID: 3839291

Wilson et al (1990) 5-Hydroxytryptamine3 receptors mediate tachycardia in conscious instrumented dogs. J.Pharmacol.Exp.Ther. 252 683 PMID: 1968974


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1 Citation for α-Methyl-5-hydroxytryptamine maleate

Citations are publications that use Tocris products. Selected citations for α-Methyl-5-hydroxytryptamine maleate include:

Coulon et al (2011) Activity Modes in Thalamocortical Relay Neurons are Modulated by G(q)/G(11) Family G-proteins - Serotonergic and Glutamatergic Signaling. Front Cell Neurosci 4 132 PMID: 21267426


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