α-Conotoxin PnIA

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Cat.No. 3123 - alpha-Conotoxin PnIA | Gly-Cys-Cys-Ser-Leu-Pro-Pro-Cys-Ala-Ala-Asn-Asn-Pro-Asp-Tyr-Cys-NH2 | CAS No. 705300-84-1
Description: Selective α3β2 nAChR antagonist
Datasheet
Citations
Reviews
Literature (3)

Biological Activity

Selective antagonist of α3β2 nAChR receptors (IC50 values are 9.56 and 252 nM for α3β2 and α7 receptors respectively).

Licensing Information

Sold under license from University of Utah

Technical Data

M. Wt 1622.82
Formula C65H95N19O22S4
Sequence GCCSLPPCAANNPDYC

(Modifications: Cys-16 = C-terminal amide, Disulfide bridge between 2 - 8, 3 - 16)

Storage Desiccate at -20°C
CAS Number 705300-84-1
PubChem ID 73755066
InChI Key VUVGEYBNLLGGBG-MVPSLEAZSA-N
Smiles [H]NCC(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H]3CCCN3C(=O)[C@@H]3CCCN3C(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CC3=CC=C(O)C=C3)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC2=O)C(N)=O)NC1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 5 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Fainzilber et al (1994) New mollusc-specific α-conotoxins block Aplysia neuronal acetylcholine receptors. Biochemistry 33 9523 PMID: 8068627

Luo et al (1999) Single-residue alteration in α-conotoxin PnIA switches its nAChR subtype selectivity. Biochemistry 38 14542 PMID: 10545176

Everhart et al (2003) Identification of residues that confer α-conotoxin-PnIA sensitivity on the α3 subunit of neuronal nicotinic acetylcholine receptors. J.Pharmacol.Exp.Ther. 306 664 PMID: 12734390


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Citations for α-Conotoxin PnIA

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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