Nicotinic receptor antagonist that displays selectivity for homomeric α7 and α9 receptors (IC50 values are 220 and 1800 nM respectively). Displays no effect on α2β2, α3β2, α4β2, α2β4, α3β3 and α4β4 subunit combinations.
Sold under license from University of Utah
(Modifications: Cys-12 = C-terminal amide, Disulfide bridge between 2 - 8, 3 - 12)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 1 mg/ml in 20% acetonitrile / water|
Preparing Stock Solutions
The following data is based on the product molecular weight 1351.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.74 mL||3.7 mL||7.4 mL|
|5 mM||0.15 mL||0.74 mL||1.48 mL|
|10 mM||0.07 mL||0.37 mL||0.74 mL|
|50 mM||0.01 mL||0.07 mL||0.15 mL|
References are publications that support the products' biological activity.
McIntosh et al (1994) A nicotinic acetylcholine receptor ligand of unique specificity, α-conotoxin ImI. J.Biol.Chem. 269 16733 PMID: 8206995
Johnson et al (1995) α-Conotoxin ImI exhibits subtype-specific nicotinic acetylcholine receptor blockade: preferential inhibition of homomeric α7 and α9 receptors. Mol.Pharmacol. 48 194 PMID: 7651351
Pereira et al (1996) α-Conotoxin-ImI: a competitive antagonist at α-Bungarotoxin-sensitive neuronal nicotinic receptors in hippocampal neurons. J.Pharmacol.Exp.Ther. 278 1472 PMID: 8819535
If you know of a relevant reference for α-Conotoxin ImI, please let us know.
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Keywords: alpha-conotoxin ImI, supplier, α7, alpha7, a7, α9, alpha9, a9, selective, nAChR, antagonists, Nicotinic, Receptors, Acetylcholine, Non-Selective, α-conotoxin, alpha-conotoxin, ImI, a-conotoxinImI, conotoxins, venoms, Nicotinic, (a7), Receptors, Nicotinic, Receptors, (Other, Subtypes), Nicotinic, (a7), Receptors, Tocris Bioscience
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