α-Conotoxin ImI

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Cat.No. 3119 - alpha-conotoxin ImI | Gly-Cys-Cys-Ser-Asp-Pro-Arg-Cys-Ala-Trp-Arg-Cys-NH2 | CAS No. 156467-85-5
Description: α7 and α9 selective nAChR antagonist
Datasheet
Citations
Literature

Biological Activity

Nicotinic receptor antagonist that displays selectivity for homomeric α7 and α9 receptors (IC50 values are 220 and 1800 nM respectively). Displays no effect on α2β2, α3β2, α4β2, α2β4, α3β3 and α4β4 subunit combinations.

Licensing Information

Sold under license from University of Utah

Technical Data

M. Wt 1351.6
Formula C52H78N20O15S4
Sequence GCCSDPRCAWRC

(Modifications: Cys-12 = C-terminal amide, Disulfide bridge between 2 - 8, 3 - 12)

Storage Store at -20°C
CAS Number 156467-85-5
PubChem ID 76324742
InChI Key AIKMSOHWSGWCNX-VAYQAVKTSA-N
Smiles [H]NCC(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC3=CNC4=C3C=CC=C4)NC(=O)[C@H](C)NC2=O)C(N)=O)NC1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in 20% acetonitrile / water

Preparing Stock Solutions

The following data is based on the product molecular weight 1351.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.74 mL 3.7 mL 7.4 mL
5 mM 0.15 mL 0.74 mL 1.48 mL
10 mM 0.07 mL 0.37 mL 0.74 mL
50 mM 0.01 mL 0.07 mL 0.15 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

McIntosh et al (1994) A nicotinic acetylcholine receptor ligand of unique specificity, α-conotoxin ImI. J.Biol.Chem. 269 16733 PMID: 8206995

Johnson et al (1995) α-Conotoxin ImI exhibits subtype-specific nicotinic acetylcholine receptor blockade: preferential inhibition of homomeric α7 and α9 receptors. Mol.Pharmacol. 48 194 PMID: 7651351

Pereira et al (1996) α-Conotoxin-ImI: a competitive antagonist at α-Bungarotoxin-sensitive neuronal nicotinic receptors in hippocampal neurons. J.Pharmacol.Exp.Ther. 278 1472 PMID: 8819535


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Citations for α-Conotoxin ImI

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Pathways for α-Conotoxin ImI

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