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Submit Reviewα-Conotoxin AuIB
Description: Selective α3β4 nAChR antagonist
Purity: ≥95% (HPLC)
Biological Activity for α-Conotoxin AuIB
α-Conotoxin AuIB is a selective antagonist of α3β4 nicotinic acetylcholine receptors. Displays > 100-fold selectivity over other receptor subunit combinations including α2β2, α2β4, α3β2, α4β2, α4β4 and α1β1γδ.
Licensing Information
Sold under license from University of Utah
Technical Data for α-Conotoxin AuIB
| M. Wt | 1572.76 |
| Formula | C65H89N17O21S4 |
| Sequence |
GCCSYPPCFATNPDC (Modifications: Cys-15 = C-terminal amide, Disulfide bridges: 2-8, 3-15) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 216299-21-7 |
| PubChem ID | 73755065 |
| InChI Key | SVNSCQIKKAACJG-SBLJLSJOSA-N |
| Smiles | C[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@H]3C(=O)N[C@H](C(=O)N[C@H](C(=O)N4CCC[C@H]4C(=O)N5CCC[C@H]5C(=O)N[C@@H](CSSC[C@@H](C(=O)N3)NC(=O)CN)C(=O)N[C@H](C(=O)N1)CC6=CC=CC=C6)CC7=CC=C(C=C7)O)CO)C(=O)N)CC(=O)O)CC(=O)N)[C@@H](C)O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for α-Conotoxin AuIB
| Solubility | Soluble to 5 mg/ml in water |
Product Datasheets for α-Conotoxin AuIB
References for α-Conotoxin AuIB
References are publications that support the biological activity of the product.
Luo et al (1998) α-Conotoxin AuIB selectively blocks α3β4 nicotinic acetylcholine receptors and nicotine-evoked NE release. J.Neurosci. 18 8571 PMID: 9786965
Nai et al (2003) Relating neuronal nicotinic acetylcholine receptor subtypes defined by subunit composition and channel function. Mol.Pharmacol. 63 311 PMID: 12527802
Park et al (2006) An α3β4 subunit combination acts as a major functional nicotinic acetylcholine receptor in male rat pelvic ganglion neurons. Pflugers Arch. 452 775 PMID: 16715294
If you know of a relevant reference for α-Conotoxin AuIB, please let us know.
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Citations for α-Conotoxin AuIB
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Currently there are no citations for α-Conotoxin AuIB. Do you know of a great paper that uses α-Conotoxin AuIB from Tocris? Please let us know.
Reviews for α-Conotoxin AuIB
Average Rating: 5 (Based on 1 Review.)
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Gold standard to compare analgesic drugs.
By
Luiz Alexandre Magno on 02/17/2022
Assay Type: In Vivo
Species: Rat
In our lab we used this product as a gold standard to compare analgesic effects of different toxins. It works very well in rodents.
Intrathecal administration works great
Literature in this Area
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