α-Conotoxin AuIB

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Cat.No. 3120 - alpha-Conotoxin AuIB | Gly-Cys-Cys-Ser-Tyr-Pro-Pro-Cys-Phe-Ala-Thr-Asn-Pro-Asp-Cys-NH2 | CAS No. 216299-21-7
Description: Selective α3β4 nAChR antagonist
Datasheet
Citations
Reviews
Literature

Biological Activity

Selective antagonist of α3β4 nicotinic acetylcholine receptors. Displays > 100-fold selectivity over other receptor subunit combinations including α2β2, α2β4, α3β2, α4β2, α4β4 and α1β1γδ.

Licensing Information

Sold under license from University of Utah

Technical Data

M. Wt 1572.76
Formula C65H89N17O21S4
Sequence GCCSYPPCFATNPDC

(Modifications: Cys-15 = C-terminal amide, Disulfide bridge between 2 - 8, 3 - 15)

Storage Desiccate at -20°C
CAS Number 216299-21-7
PubChem ID 73755065
InChI Key SVNSCQIKKAACJG-SBLJLSJOSA-N
Smiles [H]NCC(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H]3CCCN3C(=O)[C@@H]3CCCN3C(=O)[C@H](CC3=CC=C(O)C=C3)NC(=O)[C@H](CO)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC3=CC=CC=C3)NC2=O)[C@@H](C)O)C(N)=O)NC1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 5 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Luo et al (1998) α-Conotoxin AuIB selectively blocks α3β4 nicotinic acetylcholine receptors and nicotine-evoked NE release. J.Neurosci. 18 8571 PMID: 9786965

Nai et al (2003) Relating neuronal nicotinic acetylcholine receptor subtypes defined by subunit composition and channel function. Mol.Pharmacol. 63 311 PMID: 12527802

Park et al (2006) An α3β4 subunit combination acts as a major functional nicotinic acetylcholine receptor in male rat pelvic ganglion neurons. Pflugers Arch. 452 775 PMID: 16715294


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Citations for α-Conotoxin AuIB

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Literature in this Area

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