A 85380 dihydrochloride

Pricing Availability   Qty
Description: High affinity and selective α4β2 nAChR agonist
Chemical Name: 3-[(2S)-2-Azetidinylmethoxy]-pyridine dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)

Biological Activity for A 85380 dihydrochloride

A 85380 dihydrochloride is a high affinity and selective α4β2 nACh receptor agonist (Ki values are 0.05, 148 and 314 nM for α4β2, α7 and α1β1δγ receptors respectively). Stimulates cation efflux in K177 cells expressing α4β2.

Technical Data for A 85380 dihydrochloride

M. Wt 237.13
Formula C9H12N2O.2HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 174740-86-4
PubChem ID 10399247
InChI Key GVEVDINKRFDXFP-JZGIKJSDSA-N
Smiles [C@@H]1(COC2=CC=CN=C2)CCN1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for A 85380 dihydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 23.71 100
DMSO 23.71 100

Preparing Stock Solutions for A 85380 dihydrochloride

The following data is based on the product molecular weight 237.13. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.22 mL 21.09 mL 42.17 mL
5 mM 0.84 mL 4.22 mL 8.43 mL
10 mM 0.42 mL 2.11 mL 4.22 mL
50 mM 0.08 mL 0.42 mL 0.84 mL

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Product Datasheets for A 85380 dihydrochloride

Certificate of Analysis / Product Datasheet
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References for A 85380 dihydrochloride

References are publications that support the biological activity of the product.

Abreo et al (1996) Novel 3-Pyridyl ethers with subnanomolar affinity for central neuronal nicotinic acetylcholine receptors. J.Med.Chem. 39 817 PMID: 8632405

Sullivan et al (1996) A-85380 [3-(2(S)-azetidinylmethoxy) pyridine]: in vitro pharmacological properties of a novel, high affinity α4β2 nicotinic acetylcholine receptor ligand. Neuropharmacology 35 725 PMID: 8887981


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Citations for A 85380 dihydrochloride

Citations are publications that use Tocris products.

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Reviews for A 85380 dihydrochloride

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Nicotinic ACh Receptors Scientific Review

Nicotinic ACh Receptors Scientific Review

Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.

Alzheimer's Disease Poster

Alzheimer's Disease Poster

Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.