A 85380 dihydrochloride

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Cat.No. 5017 - A 85380 dihydrochloride | C9H12N2O.2HCl | CAS No. 174740-86-4
Description: High affinity and selective α4β2 agonist
Chemical Name: 3-[(2S)-2-Azetidinylmethoxy]-pyridine dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

High affinity and selective α4β2 nACh receptor agonist (Ki values are 0.05, 148 and 314 nM for α4β2, α7 and α1β1δγ receptors respectively). Stimulates cation efflux in K177 cells expressing α4β2.

Technical Data

M. Wt 237.13
Formula C9H12N2O.2HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 174740-86-4
PubChem ID 10399247
InChI Key GVEVDINKRFDXFP-JZGIKJSDSA-N
Smiles [C@@H]1(COC2=CC=CN=C2)CCN1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 23.71 100
water 23.71 100

Preparing Stock Solutions

The following data is based on the product molecular weight 237.13. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.22 mL 21.09 mL 42.17 mL
5 mM 0.84 mL 4.22 mL 8.43 mL
10 mM 0.42 mL 2.11 mL 4.22 mL
50 mM 0.08 mL 0.42 mL 0.84 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Abreo et al (1996) Novel 3-Pyridyl ethers with subnanomolar affinity for central neuronal nicotinic acetylcholine receptors. J.Med.Chem. 39 817 PMID: 8632405

Sullivan et al (1996) A-85380 [3-(2(S)-azetidinylmethoxy) pyridine]: in vitro pharmacological properties of a novel, high affinity α4β2 nicotinic acetylcholine receptor ligand. Neuropharmacology 35 725 PMID: 8887981


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Citations for A 85380 dihydrochloride

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