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Submit ReviewA 85380 dihydrochloride
Description: High affinity and selective α4β2 nAChR agonist
Chemical Name: 3-[(2S)-2-Azetidinylmethoxy]-pyridine dihydrochloride
Purity: ≥98% (HPLC)
Biological Activity for A 85380 dihydrochloride
A 85380 dihydrochloride is a high affinity and selective α4β2 nACh receptor agonist (Ki values are 0.05, 148 and 314 nM for α4β2, α7 and α1β1δγ receptors respectively). Stimulates cation efflux in K177 cells expressing α4β2.
Technical Data for A 85380 dihydrochloride
| M. Wt | 237.13 |
| Formula | C9H12N2O.2HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 174740-86-4 |
| PubChem ID | 10399247 |
| InChI Key | GVEVDINKRFDXFP-JZGIKJSDSA-N |
| Smiles | [C@@H]1(COC2=CC=CN=C2)CCN1.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for A 85380 dihydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 23.71 | 100 | |
| DMSO | 23.71 | 100 |
Preparing Stock Solutions for A 85380 dihydrochloride
The following data is based on the product molecular weight 237.13. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.22 mL | 21.09 mL | 42.17 mL |
| 5 mM | 0.84 mL | 4.22 mL | 8.43 mL |
| 10 mM | 0.42 mL | 2.11 mL | 4.22 mL |
| 50 mM | 0.08 mL | 0.42 mL | 0.84 mL |
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Product Datasheets for A 85380 dihydrochloride
References for A 85380 dihydrochloride
References are publications that support the biological activity of the product.
Abreo et al (1996) Novel 3-Pyridyl ethers with subnanomolar affinity for central neuronal nicotinic acetylcholine receptors. J.Med.Chem. 39 817 PMID: 8632405
Sullivan et al (1996) A-85380 [3-(2(S)-azetidinylmethoxy) pyridine]: in vitro pharmacological properties of a novel, high affinity α4β2 nicotinic acetylcholine receptor ligand. Neuropharmacology 35 725 PMID: 8887981
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