A 80426 mesylate

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Cat.No. 2341 - A 80426 mesylate | C23H27NO2.CH3SO3H | CAS No. 152148-64-6
Description: High affinity α2 antagonist. Also 5-HT uptake inhibitor
Chemical Name: N-Methyl-N-[[(1R)-1,2,3,4-tetrahydro-5-methoxy-1-naphthalenyl]methyl]-6-benzofuranethanamine mesylate
Purity: ≥98% (HPLC)
Literature (6)

Biological Activity

High affinity α2-adrenoceptor antagonist and selective 5-HT uptake inhibitor (Ki values are 2.01 and 3.77 nM respectively). Displays low affinity at a variety of structurally homologous GPCRs.

Technical Data

M. Wt 445.57
Formula C23H27NO2.CH3SO3H
Storage Desiccate at +4°C
Purity ≥98% (HPLC)
CAS Number 152148-64-6
PubChem ID 10366248
Smiles COC1=C2C([C@H](CN(CCC3=CC(OC=C4)=C4C=C3)C)CCC2)=CC=C1.CS(=O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 4.46 10
DMSO 44.56 100

Preparing Stock Solutions

The following data is based on the product molecular weight 445.57. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.24 mL 11.22 mL 22.44 mL
5 mM 0.45 mL 2.24 mL 4.49 mL
10 mM 0.22 mL 1.12 mL 2.24 mL
50 mM 0.04 mL 0.22 mL 0.45 mL

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References are publications that support the biological activity of the product.

Meyer et al (1995) Synthesis and pharmacological characterisation of A-80426: a putative novel antidepressant combining α-2 antagonism with 5-HT uptake inhibition. Bioorg.Med.Chem.Letts. 5 2287

Giardina et al (1995) A-80426, a potent and selective β2-adrenoceptor antagonist with serotonin uptake-blocking activity and putative antidepressant-like effects: II. Pharmacology profile. Drug Devel.Res. 35 246

If you know of a relevant reference for A 80426 mesylate, please let us know.

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