A 80426 mesylate

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Cat.No. 2341 - A 80426 mesylate | C23H27NO2.CH3SO3H | CAS No. 152148-64-6
Description: High affinity α2 antagonist. Also 5-HT uptake inhibitor
Chemical Name: N-Methyl-N-[[(1R)-1,2,3,4-tetrahydro-5-methoxy-1-naphthalenyl]methyl]-6-benzofuranethanamine mesylate
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

High affinity α2-adrenoceptor antagonist and selective 5-HT uptake inhibitor (Ki values are 2.01 and 3.77 nM respectively). Displays low affinity at a variety of structurally homologous GPCRs.

Technical Data

M. Wt 445.57
Formula C23H27NO2.CH3SO3H
Storage Desiccate at +4°C
Purity ≥98% (HPLC)
CAS Number 152148-64-6
PubChem ID 10366248
InChI Key RKQPEIGWZATOHW-FYZYNONXSA-N
Smiles COC1=C2C([C@H](CN(CCC3=CC(OC=C4)=C4C=C3)C)CCC2)=CC=C1.CS(=O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 44.56 100
water 4.46 10

Preparing Stock Solutions

The following data is based on the product molecular weight 445.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.24 mL 11.22 mL 22.44 mL
5 mM 0.45 mL 2.24 mL 4.49 mL
10 mM 0.22 mL 1.12 mL 2.24 mL
50 mM 0.04 mL 0.22 mL 0.45 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Meyer et al (1995) Synthesis and pharmacological characterisation of A-80426: a putative novel antidepressant combining α-2 antagonism with 5-HT uptake inhibition. Bioorg.Med.Chem.Letts. 5 2287 PMID:

Giardina et al (1995) A-80426, a potent and selective β2-adrenoceptor antagonist with serotonin uptake-blocking activity and putative antidepressant-like effects: II. Pharmacology profile. Drug Devel.Res. 35 246 PMID:


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Citations for A 80426 mesylate

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Literature in this Area

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Pathways for A 80426 mesylate

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