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Submit ReviewA 71623
Description: Potent and selective CCK1agonist. Suppresses feeding
Chemical Name: N-[(1,1-Dimethylethoxy)carbonyl]-L-tryptophyl-N6-[[(2-methylphenyl)amino]carbonyl]-L-lysyl-L-a-aspartyl-Na-methyl-L-phenylalaninamide
Biological Activity for A 71623
Potent CCK1 agonist (IC50 = 3.7 nM) with 1200-fold selectivity over the CCK2 receptor. Suppresses food intake following central or peripheral administration.
Technical Data for A 71623
| M. Wt | 840.97 |
| Formula | C44H56N8O9 |
| Storage | Desiccate at -20°C |
| CAS Number | 130408-77-4 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for A 71623
Certificate of Analysis is currently unavailable on-line.
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References for A 71623
References are publications that support the biological activity of the product.
Asin et al (1992) A-71623, a selective CCK-A receptor agonist, suppresses food intake in the mouse, dog, and monkey. Pharmacol.Biochem.Behav. 42 699 PMID: 1513850
DeNinno et al (1990) Development of CCK-tetrapeptide analogues as potent and selective CCK-A receptor agonists. J.Med.Chem. 33 2951
Lin et al (1990) Characterization of two novel cholecystokinin tetrapeptide (30-33) analogues, A-71623 and A-70874, that exhibit high potency and selectivity for cholecystokinin-A receptors. Mol.Pharmacol. 39 346
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Keywords: A 71623, A 71623 supplier, A-71623, CCK, CCK1, CCK-1, Obesity, Feeding, Anorexia, Cholecystokinin, CCK-8, Receptor, 2036, Tocris Bioscience
Citations for A 71623
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.