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Submit ReviewA 71623
Discontinued Product
A 71623 (Cat. No. 2036) has been withdrawn from sale for commercial reasons.
Description: Potent and selective CCK1agonist. Suppresses feeding
Chemical Name: N-[(1,1-Dimethylethoxy)carbonyl]-L-tryptophyl-N6-[[(2-methylphenyl)amino]carbonyl]-L-lysyl-L-a-aspartyl-Na-methyl-L-phenylalaninamide
Biological Activity for A 71623
Potent CCK1 agonist (IC50 = 3.7 nM) with 1200-fold selectivity over the CCK2 receptor. Suppresses food intake following central or peripheral administration.
Technical Data for A 71623
| M. Wt | 840.97 |
| Formula | C44H56N8O9 |
| Storage | Desiccate at -20°C |
| CAS Number | 130408-77-4 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for A 71623
Certificate of Analysis is currently unavailable on-line.
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References for A 71623
References are publications that support the biological activity of the product.
Asin et al (1992) A-71623, a selective CCK-A receptor agonist, suppresses food intake in the mouse, dog, and monkey. Pharmacol.Biochem.Behav. 42 699 PMID: 1513850
DeNinno et al (1990) Development of CCK-tetrapeptide analogues as potent and selective CCK-A receptor agonists. J.Med.Chem. 33 2951
Lin et al (1990) Characterization of two novel cholecystokinin tetrapeptide (30-33) analogues, A-71623 and A-70874, that exhibit high potency and selectivity for cholecystokinin-A receptors. Mol.Pharmacol. 39 346
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Keywords: A 71623, A 71623 supplier, A-71623, CCK, CCK1, CCK-1, Obesity, Feeding, Anorexia, Cholecystokinin, CCK-8, Receptor, 2036, Tocris Bioscience
Citations for A 71623
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