A 350619 hydrochloride

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Cat.No. 2753 - A 350619 hydrochloride | C21H25ClN2OS.HCl | CAS No. 1217201-17-6
Description: Soluble guanylyl cyclase (sGC) activator
Chemical Name: 3-[2-[(4-Chlorophenyl)thiophenyl]-N-[4-(dimethylamino)butyl]-2-propenamide hydrochloride
Purity: ≥99% (HPLC)

Biological Activity

Activator of soluble guanylyl cyclase (sGC). Activates basal sGC and synergistically activates sGC in the presence of NO. Relaxes cavernosum smooth muscle in vitro and induces penile erections in rats. Induces a sustained increase in skin blood flow in vivo.

Technical Data

M. Wt 425.41
Formula C21H25ClN2OS.HCl
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1217201-17-6
PubChem ID 56924282
Smiles O=C(NCCCCN(C)C)/C=C/C1=C(SC2=CC=C(Cl)C=C2)C=CC=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 42.54 100

Preparing Stock Solutions

The following data is based on the product molecular weight 425.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.35 mL 11.75 mL 23.51 mL
5 mM 0.47 mL 2.35 mL 4.7 mL
10 mM 0.24 mL 1.18 mL 2.35 mL
50 mM 0.05 mL 0.24 mL 0.47 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Miller et al (2003) A-350619: a novel activator of soluble guanylyl cyclase. Life Sci. 72 1015 PMID: 12495780

Evgenov et al (2006) NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential. Nat.Rev.Drug Discov. 5 755 PMID: 16955067

Kotzki et al (2013) Anodal iontophoresis of a soluble guanylate cyclase stimulator induces a sustained increase in skin blood flow in rats. J.Pharmacol.Exp.Ther. 346 424 PMID: 23838678

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