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Submit ReviewA 350619 hydrochloride
Description: Soluble guanylyl cyclase (sGC) activator
Chemical Name: 3-[2-[(4-Chlorophenyl)thiophenyl]-N-[4-(dimethylamino)butyl]-2-propenamide hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for A 350619 hydrochloride
A 350619 hydrochloride is an activator of soluble guanylyl cyclase (sGC). Activates basal sGC and synergistically activates sGC in the presence of NO. Relaxes cavernosum smooth muscle in vitro and induces penile erections in rats. Induces a sustained increase in skin blood flow in vivo.
Technical Data for A 350619 hydrochloride
| M. Wt | 425.41 |
| Formula | C21H25ClN2OS.HCl |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 1217201-17-6 |
| PubChem ID | 56924282 |
| InChI Key | PDVBHWZPRQFKJS-KYIGKLDSSA-N |
| Smiles | O=C(NCCCCN(C)C)/C=C/C1=C(SC2=CC=C(Cl)C=C2)C=CC=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for A 350619 hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 42.54 | 100 |
Preparing Stock Solutions for A 350619 hydrochloride
The following data is based on the product molecular weight 425.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.35 mL | 11.75 mL | 23.51 mL |
| 5 mM | 0.47 mL | 2.35 mL | 4.7 mL |
| 10 mM | 0.24 mL | 1.18 mL | 2.35 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.47 mL |
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Product Datasheets for A 350619 hydrochloride
References for A 350619 hydrochloride
References are publications that support the biological activity of the product.
Miller et al (2003) A-350619: a novel activator of soluble guanylyl cyclase. Life Sci. 72 1015 PMID: 12495780
Evgenov et al (2006) NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential. Nat.Rev.Drug Discov. 5 755 PMID: 16955067
Kotzki et al (2013) Anodal iontophoresis of a soluble guanylate cyclase stimulator induces a sustained increase in skin blood flow in rats. J.Pharmacol.Exp.Ther. 346 424 PMID: 23838678
If you know of a relevant reference for A 350619 hydrochloride, please let us know.
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