A 196

Pricing Availability   Qty
Cat.No. 6167 - A 196 | C18H16Cl2N4 | CAS No. 1982372-88-2
Description: Potent and selective SUV420H1/H2 inhibitor
Chemical Name: 6,7-Dichloro-N-cyclopentyl-4-(4-pyridinyl)-1-phthalazinamine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent and selective SUV420H1/H2 inhibitor (IC50 values are 25 and 144 nM respectively). Exhibits 100-fold selectivity over other histone methyltransferases and non-epigenetic targets. Inhibits the di- and tri-methylation of H4K20me in multiple cell lines (IC50 < 1 μM).

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the A-196 probe summary on the SGC website.

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of A196 is reviewed on the Chemical Probes website.

Technical Data

M. Wt 359.25
Formula C18H16Cl2N4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1982372-88-2
Smiles ClC1=CC2=C(C(C3=CC=NC=C3)=NN=C2NC4CCCC4)C=C1Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.18 20

Preparing Stock Solutions

The following data is based on the product molecular weight 359.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 13.92 mL 69.59 mL 139.18 mL
1 mM 2.78 mL 13.92 mL 27.84 mL
2 mM 1.39 mL 6.96 mL 13.92 mL
10 mM 0.28 mL 1.39 mL 2.78 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References

References are publications that support the biological activity of the product.

Bromberg et al (2017) The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity. Nat.Chem.Biol. 13 317 PMID: 28114273


If you know of a relevant reference for A 196, please let us know.

View Related Products by Product Action

View all Other Lysine Methyltransferase Inhibitors

Keywords: A 196, A 196 supplier, A196, methyltransferases, histones, inhibitors, inhibits, HMTs, MLL, leukemia, mll-rearranged, H4K20me, potent, selective, Other, Lysine, Methyltransferases, 6167, Tocris Bioscience

Citations for A 196

Citations are publications that use Tocris products.

Currently there are no citations for A 196. Do you know of a great paper that uses A 196 from Tocris? Please let us know.

Reviews for A 196

There are currently no reviews for this product. Be the first to review A 196 and earn rewards!

Have you used A 196?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


New Product Guide

New Product Guide (Spring/Summer 2018)

Our new product guide highlights over 200 new products added to the Tocris Bioscience range during the second half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Aptamers
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells