9-Phenanthrol
Biological Activity
Selective TRPM4 blocker (IC50 = 20 μM in HEK293 cells). Exhibits no effect on CFTR or TRPM5 (at 0.25 and 1 mM respectively). Abolishes arrhythmias induced by hypoxia in a mouse heart model.
Technical Data
| M. Wt | 194.23 |
| Formula | C14H10O |
| Storage | Store at +4°C |
| CAS Number | 484-17-3 |
| PubChem ID | 10229 |
| InChI Key | DZKIUEHLEXLYKM-UHFFFAOYSA-N |
| Smiles | OC2=CC1=C(C3=C2C=CC=C3)C=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 19.42 | 100 | |
| ethanol | 19.42 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 194.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.15 mL | 25.74 mL | 51.49 mL |
| 5 mM | 1.03 mL | 5.15 mL | 10.3 mL |
| 10 mM | 0.51 mL | 2.57 mL | 5.15 mL |
| 50 mM | 0.1 mL | 0.51 mL | 1.03 mL |
Molarity Calculator
Reconstitution Calculator
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Simard et al (2012) Transient receptor potential melastatin 4 inhibitor 9-phenanthrol abolishes arrhythmias induced by hypoxia and re-oxygenation in mouse ventricle. Br.J.Pharmacol. 165 2354 PMID: 22014185
Grand et al (2008) 9-phenanthrol inhibits human TRPM4 but not TRPM5 cationic channels. Br.J.Pharmacol. 153 1697 PMID: 18297105
If you know of a relevant reference for 9-Phenanthrol, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: 9-Phenanthrol, supplier, Transient, receptor, potential, TRPM4, blockers, TRP, channels, arrhythmias, cardiac, heart, anti-arrhythmic, depolarisations, TRPM, Tocris Bioscience
Citations for 9-Phenanthrol
Citations are publications that use Tocris products.
Currently there are no citations for 9-Phenanthrol. Do you know of a great paper that uses 9-Phenanthrol from Tocris? If so please let us know.
Literature in this Area
Pain Research Product Guide
A collection of over 250 products for pain research, the guide includes research tools for the study of:
- Nociception
- Ion Channels
- G-Protein-Coupled Receptors
- Intracellular Signaling
Pain Poster
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.
