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Cat.No. 4999 - 9-Phenanthrol | C14H10O | CAS No. 484-17-3
Description: Selective TRPM4 blocker
Chemical Name: 9-Hydroxyphenanthrene

Biological Activity

Selective TRPM4 blocker (IC50 = 20 μM in HEK293 cells). Exhibits no effect on CFTR or TRPM5 (at 0.25 and 1 mM respectively). Abolishes arrhythmias induced by hypoxia in a mouse heart model.

Technical Data

M. Wt 194.23
Formula C14H10O
Storage Store at +4°C
CAS Number 484-17-3
PubChem ID 10229
Smiles OC2=CC1=C(C3=C2C=CC=C3)C=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 19.42 100
ethanol 19.42 100

Preparing Stock Solutions

The following data is based on the product molecular weight 194.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.15 mL 25.74 mL 51.49 mL
5 mM 1.03 mL 5.15 mL 10.3 mL
10 mM 0.51 mL 2.57 mL 5.15 mL
50 mM 0.1 mL 0.51 mL 1.03 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Simard et al (2012) Transient receptor potential melastatin 4 inhibitor 9-phenanthrol abolishes arrhythmias induced by hypoxia and re-oxygenation in mouse ventricle. Br.J.Pharmacol. 165 2354 PMID: 22014185

Grand et al (2008) 9-phenanthrol inhibits human TRPM4 but not TRPM5 cationic channels. Br.J.Pharmacol. 153 1697 PMID: 18297105

If you know of a relevant reference for 9-Phenanthrol, please let us know.

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Citations for 9-Phenanthrol

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Pathways for 9-Phenanthrol


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