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Biological Activity for 9-Phenanthrol
9-Phenanthrol is a selective TRPM4 blocker (IC50 = 20 μM in HEK293 cells). Exhibits no effect on CFTR or TRPM5 (at 0.25 and 1 mM respectively). Abolishes arrhythmias induced by hypoxia in a mouse heart model.
Technical Data for 9-Phenanthrol
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for 9-Phenanthrol
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for 9-Phenanthrol
The following data is based on the product molecular weight 194.23. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||5.15 mL||25.74 mL||51.49 mL|
|5 mM||1.03 mL||5.15 mL||10.3 mL|
|10 mM||0.51 mL||2.57 mL||5.15 mL|
|50 mM||0.1 mL||0.51 mL||1.03 mL|
References for 9-Phenanthrol
References are publications that support the biological activity of the product.
Simard et al (2012) Transient receptor potential melastatin 4 inhibitor 9-phenanthrol abolishes arrhythmias induced by hypoxia and re-oxygenation in mouse ventricle. Br.J.Pharmacol. 165 2354 PMID: 22014185
Grand et al (2008) 9-phenanthrol inhibits human TRPM4 but not TRPM5 cationic channels. Br.J.Pharmacol. 153 1697 PMID: 18297105
If you know of a relevant reference for 9-Phenanthrol, please let us know.
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Keywords: 9-Phenanthrol, 9-Phenanthrol supplier, Transient, receptor, potential, TRPM4, blockers, TRP, channels, arrhythmias, cardiac, heart, anti-arrhythmic, depolarisations, TRPM, 4999, Tocris Bioscience
4 Citations for 9-Phenanthrol
Citations are publications that use Tocris products. Selected citations for 9-Phenanthrol include:
Lin et al (2017) Differential Contribution of Ca2+-Dependent Mechanisms to Hyperexcitability in Layer V Neurons of the Medial Entorhinal Cortex. Front Cell Neurosci 11 182 PMID: 28713246
Douglas A et al (2021) TRPM4 mediates a subthreshold membrane potential oscillation in respiratory chemoreceptor neurons that drives pacemaker firing and breathing. Cell Rep 34 108714 PMID: 33535052
Virginie et al (2021) Trpm5 channels encode bistability of spinal motoneurons and ensure motor control of hindlimbs in mice. Nat Commun 12 6815 PMID: 34819493
O'Malley et al (2020) TRPM4 Conductances in Thalamic Reticular Nucleus Neurons Generate Persistent Firing during Slow Oscillations. J Neurosci 40 4813 PMID: 32414784
Do you know of a great paper that uses 9-Phenanthrol from Tocris? Please let us know.
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