9-Phenanthrol

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Cat.No. 4999 - 9-Phenanthrol | C14H10O | CAS No. 484-17-3
Description: Selective TRPM4 blocker
Chemical Name: 9-Hydroxyphenanthrene
Datasheet
Citations
Reviews
Literature

Biological Activity

Selective TRPM4 blocker (IC50 = 20 μM in HEK293 cells). Exhibits no effect on CFTR or TRPM5 (at 0.25 and 1 mM respectively). Abolishes arrhythmias induced by hypoxia in a mouse heart model.

Technical Data

M. Wt 194.23
Formula C14H10O
Storage Store at +4°C
CAS Number 484-17-3
PubChem ID 10229
InChI Key DZKIUEHLEXLYKM-UHFFFAOYSA-N
Smiles OC2=CC1=C(C3=C2C=CC=C3)C=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 19.42 100
ethanol 19.42 100

Preparing Stock Solutions

The following data is based on the product molecular weight 194.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.15 mL 25.74 mL 51.49 mL
5 mM 1.03 mL 5.15 mL 10.3 mL
10 mM 0.51 mL 2.57 mL 5.15 mL
50 mM 0.1 mL 0.51 mL 1.03 mL

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References

References are publications that support the biological activity of the product.

Simard et al (2012) Transient receptor potential melastatin 4 inhibitor 9-phenanthrol abolishes arrhythmias induced by hypoxia and re-oxygenation in mouse ventricle. Br.J.Pharmacol. 165 2354 PMID: 22014185

Grand et al (2008) 9-phenanthrol inhibits human TRPM4 but not TRPM5 cationic channels. Br.J.Pharmacol. 153 1697 PMID: 18297105


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