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Adenine receptor agonist (Ki = 0.0341 μM in HEK293 cells expressing an adenine binding site). Displays 190-fold increased potency at the human binding site over the rat adenine receptor (rAde1R) (Ki = 6.51 μM).
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 150.14. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||6.66 mL||33.3 mL||66.6 mL|
|5 mM||1.33 mL||6.66 mL||13.32 mL|
|10 mM||0.67 mL||3.33 mL||6.66 mL|
|50 mM||0.13 mL||0.67 mL||1.33 mL|
References are publications that support the biological activity of the product.
Borrmann et al (2009) Structure-activity relationships of adenine and deazaadenine derivatives as ligands for adenine receptors, a new purinergic receptor family. J.Med.Chem. 52 5974 PMID: 19731917
Bender et al (2002) Characterization of an orphan G protein-coupled receptor localized in the dorsal root ganglia reveals adenine as a signaling molecule. Proc.Natl.Acad.Sci. 99 8573
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Keywords: 8-Aminoadenine, 8-Aminoadenine supplier, p0, adenine, receptors, agonists, purinergic, signaling, signalling, Adenine, Receptor, 4050, Tocris Bioscience
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Literature in this Area
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