8-Aminoadenine

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Cat.No. 4050 - 8-Aminoadenine | C5H6N6 | CAS No. 28128-33-8
Description: Adenine receptor agonist
Chemical Name: 9H-Purine-6,8-diamine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Adenine receptor agonist (Ki = 0.0341 μM in HEK293 cells expressing an adenine binding site). Displays 190-fold increased potency at the human binding site over the rat adenine receptor (rAde1R) (Ki = 6.51 μM).

Technical Data

M. Wt 150.14
Formula C5H6N6
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 28128-33-8
PubChem ID 4371597
InChI Key PFUVOLUPRFCPMN-UHFFFAOYSA-N
Smiles NC2=NC1=NC=NC(N)=C1N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
2eq.HCl 15.01 100
DMSO 7.51 50

Preparing Stock Solutions

The following data is based on the product molecular weight 150.14. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6.66 mL 33.3 mL 66.6 mL
5 mM 1.33 mL 6.66 mL 13.32 mL
10 mM 0.67 mL 3.33 mL 6.66 mL
50 mM 0.13 mL 0.67 mL 1.33 mL

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References

References are publications that support the biological activity of the product.

Borrmann et al (2009) Structure-activity relationships of adenine and deazaadenine derivatives as ligands for adenine receptors, a new purinergic receptor family. J.Med.Chem. 52 5974 PMID: 19731917

Bender et al (2002) Characterization of an orphan G protein-coupled receptor localized in the dorsal root ganglia reveals adenine as a signaling molecule. Proc.Natl.Acad.Sci. 99 8573


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Citations for 8-Aminoadenine

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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P2X and P2Y Receptors

P2X and P2Y Receptors Scientific Review

Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.