7-NINA

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Cat.No. 0800 - 7-NINA | C7H4N3O2Na | CAS No. 161467-34-1
Description: Non-selective NOS inhibitor. Sodium salt of 7-nitroindazole (Cat. No. 0602)
Chemical Name: 7-Nitroindazole monosodium salt
Purity: ≥98%
Datasheet
Citations (2)
Reviews
Literature

Biological Activity

Sodium salt of the non-selective NOS inhibitor 7-nitroindazole (Cat. No. 0602).

Technical Data

M. Wt 185.12
Formula C7H4N3O2Na
Storage Desiccate at -20°C
Purity ≥98%
CAS Number 161467-34-1
PubChem ID 16760594
InChI Key DJMLKKIIBMJGIQ-UHFFFAOYSA-N
Smiles [Na+].[O-][N+](=O)C1=C2[N-]N=CC2=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 9.26 50

Preparing Stock Solutions

The following data is based on the product molecular weight 185.12. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 10.8 mL 54.02 mL 108.04 mL
2.5 mM 2.16 mL 10.8 mL 21.61 mL
5 mM 1.08 mL 5.4 mL 10.8 mL
25 mM 0.22 mL 1.08 mL 2.16 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

O'Neill et al (1996) Neuroprotective effects of 7-nitroindazole in the gerbil model of global cerebral ischaemia. Eur.J.Pharmacol. 310 115 PMID: 8884206

Silva et al (1995) Increased striatal DA efflux in vivo following inhibition of cerebral nitric oxide synthase by the novel monosodium salt of 7-nitroindazole. Br.J.Pharmacol. 114 257 PMID: 7533610


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Keywords: 7-NINA, 7-NINA supplier, Non-Selective, NOS, Nitric, Oxide, Signaling, Signalling, iNOS, nNOS, eNOS, NO, Synthases, Non-selective, 0800, Tocris Bioscience

2 Citations for 7-NINA

Citations are publications that use Tocris products. Selected citations for 7-NINA include:

Fakira et al (2012) Purkinje cell dysfunction and delayed death in plasma membrane calcium ATPase 2-heterozygous mice. J Neurosci 51 22 PMID: 22789621

Messlinger et al (2000) Involvement of nitric oxide in the modulation of dural arterial blood flow in the rat. Br J Pharmacol 129 1397 PMID: 10742295


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Literature in this Area

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