6-Iodonordihydrocapsaicin

Pricing Availability Delivery Time Qty
Cat.No. 1975 - 6-Iodonordihydrocapsaicin | C17H26INO3 | CAS No. 859171-97-4
Description: Potent, competitive vanilloid receptor antagonist
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent competitive vanilloid TRPV1 (VR1) receptor antagonist (IC50 = 10 nM). Inhibits capsaicin-induced [Ca2+]i increase in rat DRG neurons, and guinea pig bladder and trachea contractions in vitro.

Technical Data

M. Wt 419.3
Formula C17H26INO3
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 859171-97-4
PubChem ID 5149140
InChI Key AAORACFZMYMFCG-UHFFFAOYSA-N
Smiles CCCCCCCCC(=O)NCC1=CC(OC)=C(O)C=C1I

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.93 100
ethanol 20.96 50

Preparing Stock Solutions

The following data is based on the product molecular weight 419.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.38 mL 11.92 mL 23.85 mL
5 mM 0.48 mL 2.38 mL 4.77 mL
10 mM 0.24 mL 1.19 mL 2.38 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Appendino et al (2003) Halogenation of a capsaicin analogue leads to novel vanilloid TRPV1 receptor antagonists. Br.J.Pharmacol. 139 1417 PMID: 12922928


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Keywords: Potent competitive vanilloids receptors antagonists VR1 TRPV Channels Transient Receptor Potential TRPV

Citations for 6-Iodonordihydrocapsaicin

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Literature in this Area

Pain

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

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Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.

Pathways for 6-Iodonordihydrocapsaicin

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