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Submit ReviewPotent competitive vanilloid TRPV1 (VR1) receptor antagonist (IC50 = 10 nM). Inhibits capsaicin-induced [Ca2+]i increase in rat DRG neurons, and guinea pig bladder and trachea contractions in vitro.
M. Wt | 419.3 |
Formula | C17H26INO3 |
Storage | Store at RT |
Purity | ≥99% (HPLC) |
CAS Number | 859171-97-4 |
PubChem ID | 5149140 |
InChI Key | AAORACFZMYMFCG-UHFFFAOYSA-N |
Smiles | CCCCCCCCC(=O)NCC1=CC(OC)=C(O)C=C1I |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Appendino et al (2003) Halogenation of a capsaicin analogue leads to novel vanilloid TRPV1 receptor antagonists. Br.J.Pharmacol. 139 1417 PMID: 12922928
Keywords: 6-Iodonordihydrocapsaicin, 6-Iodonordihydrocapsaicin supplier, Potent, competitive, vanilloids, receptors, antagonists, VR1, TRPV, Channels, Transient, Receptor, Potential, 1975, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for 6-Iodonordihydrocapsaicin include:
Kaji et al (2011) Effects of luminal thymol on epithelial transport in human and rat colon. Am J Physiol Gastrointest Liver Physiol 300 G1132 PMID: 21372164
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.