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Discontinued Product5-Nonyloxytryptamine oxalate (Cat. No. 0901) has been withdrawn from sale for commercial reasons.
5-HT1B selective agonist, several times more potent than sumatriptan and inactive as a 5-HT1A agonist (Ki at 5-HT1B = 1 nM, selectivity over 5-HT1A > 300-fold). Mimics polysialic acid activity, stimulates neuritogenesis, myelination and Schwann cell migration in vitro.
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The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Glennon et al (1994) 5-(Nonyloxy)tryptamine: a novel high affinity-5-HT1Dβ serotonin receptor agonist. J.Med.Chem. 37 2828 PMID: 8071931
Glennon et al (1996) Binding of O-Alkyl derivatives of serotonin at human 5-HT1Dβ receptors. J.Med.Chem. 39 314 PMID: 8568822
Loers et al (2013) Nonyloxytryptamine mimics polysialic acid and modulates neuronal and glial functions in cell culture. J.Neurochem. 128 88 PMID: 23957498
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Keywords: 5-Nonyloxytryptamine oxalate, 5-Nonyloxytryptamine oxalate supplier, Selective, 5-HT1B, agonists, Serotonin, Receptors, 0901, Tocris Bioscience
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.