5-Nonyloxytryptamine oxalate

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Cat.No. 0901 - 5-Nonyloxytryptamine oxalate | C19H30N2O.C2H2O4 | CAS No. 157798-13-5
Description: Selective 5-HT1B agonist
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

5-HT1B selective agonist, several times more potent than sumatriptan and inactive as a 5-HT1A agonist (Ki at 5-HT1B = 1 nM, selectivity over 5-HT1A > 300-fold). Mimics polysialic acid activity, stimulates neuritogenesis, myelination and Schwann cell migration in vitro.

Technical Data

M. Wt 392.49
Formula C19H30N2O.C2H2O4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 157798-13-5
PubChem ID 10126593
InChI Key JORSCLBFSAAOFR-UHFFFAOYSA-N
Smiles OC(=O)C(O)=O.CCCCCCCCCOC1=CC=C2NC=C(CCN)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.25 100

Preparing Stock Solutions

The following data is based on the product molecular weight 392.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.55 mL 12.74 mL 25.48 mL
5 mM 0.51 mL 2.55 mL 5.1 mL
10 mM 0.25 mL 1.27 mL 2.55 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Glennon et al (1994) 5-(Nonyloxy)tryptamine: a novel high affinity-5-HT1Dβ serotonin receptor agonist. J.Med.Chem. 37 2828 PMID: 8071931

Glennon et al (1996) Binding of O-Alkyl derivatives of serotonin at human 5-HT1Dβ receptors. J.Med.Chem. 39 314 PMID: 8568822

Loers et al (2013) Nonyloxytryptamine mimics polysialic acid and modulates neuronal and glial functions in cell culture. J.Neurochem. 128 88 PMID: 23957498


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Keywords: 5-Nonyloxytryptamine oxalate, supplier, Selective, 5-HT1B, agonists, Serotonin, Receptors, 5-HT1B, Receptors, Tocris Bioscience

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