Potent and silent vanilloid receptor antagonist, 40-fold more potent than capsazepine (Cat. No. 0464). Binds to TRPV1 (VR1) receptors expressed in HEK293 cells with a Ki of 5.8 nM.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble in DMSO and to 100 mM in ethanol|
Preparing Stock Solutions
The following data is based on the product molecular weight 754.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.33 mL||6.63 mL||13.25 mL|
|5 mM||0.27 mL||1.33 mL||2.65 mL|
|10 mM||0.13 mL||0.66 mL||1.33 mL|
|50 mM||0.03 mL||0.13 mL||0.27 mL|
References are publications that support the biological activity of the product.
Marinelli et al (2002) Capsaicin activation of glutamatergic synaptic transmission in the rat locus coeruleus in vitro. J.Physiol. 543 531 PMID: 12205187
Wahl et al (2001) Iodo-resiniferatoxin, a new potent vanilloid receptor antagonist. Mol.Pharmacol. 59 9 PMID: 11125018
Seabrook et al (2001) Properties of iodo-resiniferatoxin - a high affinity VR1 vanilloid receptor antagonist. Soc.Neurosci.Abstr. 925.9
If you know of a relevant reference for 5'-Iodoresiniferatoxin, please let us know.
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Keywords: 5'-Iodoresiniferatoxin, 5'-Iodoresiniferatoxin supplier, Potent, silent, TRPV1, antagonists, Vanillioid, Receptors, VR1, Channels, Transient, Receptor, Potential, 5-Iodoresiniferatoxin, 5-IRTX, Iodoresiniferatoxin, 5'-IRTX, TRPV, 1362, Tocris Bioscience
13 Citations for 5'-Iodoresiniferatoxin
Citations are publications that use Tocris products. Selected citations for 5'-Iodoresiniferatoxin include:
Gao et al (2012) Transient receptor potential vanilloid type 1-dependent regulation of liver-related neurons in the paraventricular nucleus of the hypothalamus diminished in the type 1 diabetic mouse. Pain 61 1381 PMID: 22492526
Ruparel et al (2012) Plasticity of cytochrome P450 isozyme expression in rat trigeminal ganglia neurons during inflammation. J Neurosci 153 2031 PMID: 22633978
Gavva et al (2005) AMG 9810 [(E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties. J Pharmacol Exp Ther 313 474 PMID: 15615864
Musella (2017) A novel crosstalk within the endocannabinoid system controls GABA transmission in the striatum. Sci Rep 7 7363 PMID: 28779174
Vigna (2014) 5-Aminosalicylic Acid Inhibits Acute Clostridium difficile Toxin A-Induced Colitis in Rats. PLoS One 2014 389621 PMID: 25045574
Price et al (2004) Cannabinoid receptor-independent actions of the aminoalkylindole WIN 55,212-2 on trigeminal sensory neurons. Br J Pharmacol 142 257 PMID: 15155534
Woolcott et al (2015) High-fat diet-induced insulin resistance does not increase plasma anandamide levels or potentiate anandamide insulinotropic effect in isolated canine islets. J Neurosci Res 10 e0123558 PMID: 25855974
Raboune et al (2014) Novel endogenous N-acyl amides activate TRPV1-4 receptors, BV-2 microglia, and are regulated in brain in an acute model of inflammation. Front Cell Neurosci 8 195 PMID: 25136293
Capasso et al (2014) Palmitoylethanolamide normalizes intestinal motility in a model of post-inflammatory accelerated transit: involvement of CB? receptors and TRPV1 channels. Br J Pharmacol 171 4026 PMID: 24818658
El-Hashim and Jaffal (2009) Nerve growth factor enhances cough and airway obstruction via TrkA receptor- and TRPV1-dependent mechanisms. Thorax 64 791 PMID: 19497920
Xu et al (2009) Increases in transient receptor potential vanilloid-1 mRNA and protein in primary afferent neurons stimulated by protein kinase C and their possible role in neurogenic inflammation. Int J Inflam 87 482 PMID: 18752301
Zsombok et al (2011) Functional plasticity of central TRPV1 receptors in brainstem dorsal vagal complex circuits of streptozotocin-treated hyperglycemic mice. PLoS One 31 14024 PMID: 21957263
Derbenev et al (2006) Vanilloid-mediated heterosynaptic facilitation of inhibitory synaptic input to neurons of the rat dorsal motor nucleus of the vagus. J Neurosci 26 9666 PMID: 16988037
Do you know of a great paper that uses 5'-Iodoresiniferatoxin from Tocris? Please let us know.
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Literature in this Area
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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.