5-BDBD

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Cat.No. 3579 - 5-BDBD | C17H11BrN2O2 | CAS No. 768404-03-1
Description: Potent P2X4 receptor antagonist
Chemical Name: 5-(3-Bromophenyl)-1,3-dihydro-2H-benzofuro[3,2-e]-1,4-diazepin-2-one
Purity: ≥99% (HPLC)
Datasheet
Citations (10)
Literature

Biological Activity

Potent P2X4 receptor antagonist. Blocks P2X4-mediated currents in Chinese hamster ovary cells (IC50 = 0.50 μM).

Compound Libraries

5-BDBD is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 355.19
Formula C17H11BrN2O2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 768404-03-1
PubChem ID 9841560
InChI Key NKYMVQPXXTZHSF-UHFFFAOYSA-N
Smiles BrC1=CC(C(C3=C4C2=C(O3)C=CC=C2)=NCC(N4)=O)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.52 100

Preparing Stock Solutions

The following data is based on the product molecular weight 355.19. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.82 mL 14.08 mL 28.15 mL
5 mM 0.56 mL 2.82 mL 5.63 mL
10 mM 0.28 mL 1.41 mL 2.82 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Donnelly-Roberts et al (2008) Painful purinergic receptors. J.Pharmacol.Exp.Ther. 324 409 PMID: 18042830

Casati et al (2011) Cell-autonomous regulation of hematopoietic stem cell cycling activity by ATP. Cell Death Differ. 18 396 PMID: 20798687


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Keywords: 5-BDBD, supplier, potent, P2X4, antagonists, purinergic, receptors, BDBD, P2X, Receptors, P2X, Receptors, Tocris Bioscience

10 Citations for 5-BDBD

Citations are publications that use Tocris products. Selected citations for 5-BDBD include:

Chen et al (2016) Effect of P2X4R on airway inflammation and airway remodeling in allergic airway challenge in mice. Mol Med Rep 13 697 PMID: 26648454

Kawano et al (2015) Autocrine Regulation of UVA-Induced IL-6 Production via Release of ATP and Activation of P2Y Receptors. PLoS One 10 e0127919 PMID: 26030257

Mascanfroni et al (2015) Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-╬▒. Circulation 21 638 PMID: 26005855

Maslieieva and Thompson (2014) A critical role for pannexin-1 in activation of innate immune cells of the choroid plexus. Channels (Austin) 8 131 PMID: 24418937

Ilatovskaya et al (2013) Pharmacological characterization of the P2 receptors profile in the podocytes of the freshly isolated rat glomeruli. Am J Physiol Cell Physiol 305 C1050 PMID: 24048730

Shabir et al (2013) Functional expression of purinergic P2 receptors and transient receptor potential channels by the human urothelium. Nat Med 305 F396 PMID: 23720349

Vergani et al (2013) Long-term heart transplant survival by targeting the ionotropic purinergic receptor P2X7. J Biol Chem 127 463 PMID: 23250993

Trabanelli et al (2012) Extracellular ATP exerts opposite effects on activated and regulatory CD4+ T cells via purinergic P2 receptor activation. J Immunol 189 1303 PMID: 22753942

N├Ârenberg et al (2012) Positive allosteric modulation by ivermectin of human but not murine P2X7 receptors. Br J Pharmacol 167 48 PMID: 22506590

Wu et al (2011) Functional expression of P2X4 receptor in capillary endothelial cells of the cochlear spiral ligament and its role in regulating the capillary diameter. Am J Physiol Heart Circ Physiol 301 H69 PMID: 21460192


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Pathways for 5-BDBD

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