4BP-TQS

Discontinued Product

4BP-TQS (Cat. No. 4234) has been withdrawn from sale for commercial reasons.
Description: α7 nAChR agonist; acts at an allosteric site
Chemical Name: 4-(4-Bromophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (2)

Biological Activity for 4BP-TQS

4BP-TQS is an allosteric agonist at α7 nAChR. Binds at a separate site and exhibits more efficacious receptor agonism compared to acetylcholine (Cat. No. 2809), displays 8-fold lower EC50 value and 45-fold larger maximal response.

Technical Data for 4BP-TQS

M. Wt 405.31
Formula C18H17BrN2O2S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 360791-49-7
PubChem ID 2857838
InChI Key YNCXHXYZTLIZTO-UHFFFAOYSA-N
Smiles BrC1=CC=C(C2NC(C=CC(S(=O)(N)=O)=C4)=C4C3C2CC=C3)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for 4BP-TQS

References are publications that support the biological activity of the product.

Gill et al (2011) Agonist activation of α7 nicotinic acetylcholine receptors via an allosteric transmembrane site. Proc.Natl.Acad.Sci.U.S.A. 108 5867 PMID: 21436053

View Related Products by Product Action

View all Nicotinic (α7) Receptor Agonists

Keywords: 4BP-TQS, 4BP-TQS supplier, alpha7, nAChR, a7, agonists, nicotinic, α7, Nicotinic, (a7), Receptors, 4234, Tocris Bioscience

1 Citation for 4BP-TQS

Citations are publications that use Tocris products. Selected citations for 4BP-TQS include:

Zhang et al (2015) Functional Impact of 14 Single Nucleotide Polymorphisms Causing Missense Mutations of Human α7 Nicotinic Receptor. Proc Natl Acad Sci U S A 10 e0137588 PMID: 26340537


Reviews for 4BP-TQS

There are currently no reviews for this product. Be the first to review 4BP-TQS and earn rewards!

Have you used 4BP-TQS?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Nicotinic ACh Receptors Scientific Review

Nicotinic ACh Receptors Scientific Review

Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.

Alzheimer's Disease Poster

Alzheimer's Disease Poster

Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.