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Discontinued Product
4234 has been discontinued.
Description: α7 nAChR agonist; acts at an allosteric site
Chemical Name: 4-(4-Bromophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide
Purity: ≥98% (HPLC)
Biological Activity for 4BP-TQS
4BP-TQS is an allosteric agonist at α7 nAChR. Binds at a separate site and exhibits more efficacious receptor agonism compared to acetylcholine (Cat. No. 2809), displays 8-fold lower EC50 value and 45-fold larger maximal response.
Technical Data for 4BP-TQS
| M. Wt | 405.31 |
| Formula | C18H17BrN2O2S |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 360791-49-7 |
| PubChem ID | 2857838 |
| InChI Key | YNCXHXYZTLIZTO-UHFFFAOYSA-N |
| Smiles | BrC1=CC=C(C2NC(C=CC(S(=O)(N)=O)=C4)=C4C3C2CC=C3)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for 4BP-TQS
References for 4BP-TQS
References are publications that support the biological activity of the product.
Gill et al (2011) Agonist activation of α7 nicotinic acetylcholine receptors via an allosteric transmembrane site. Proc.Natl.Acad.Sci.U.S.A. 108 5867 PMID: 21436053
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Keywords: 4BP-TQS, 4BP-TQS supplier, alpha7, nAChR, a7, agonists, nicotinic, α7, Nicotinic, (a7), Receptors, 4234, Tocris Bioscience
1 Citation for 4BP-TQS
Citations are publications that use Tocris products. Selected citations for 4BP-TQS include:
Zhang et al (2015) Functional Impact of 14 Single Nucleotide Polymorphisms Causing Missense Mutations of Human α7 Nicotinic Receptor. Proc Natl Acad Sci U S A 10 e0137588 PMID: 26340537
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Nicotinic ACh Receptors Scientific Review
Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.
Alzheimer's Disease Poster
Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.