4BP-TQS

Pricing Availability Delivery Time Qty
Cat.No. 4234 - 4BP-TQS | C18H17BrN2O2S | CAS No. 360791-49-7
Description: Allosteric agonist at α7 nAChR
Chemical Name: 4-(4-Bromophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Allosteric agonist at α7 nAChR. Binds at a separate site and exhibits more efficacious receptor agonism compared to acetylcholine (Cat. No. 2809), displays 8-fold lower EC50 value and 45-fold larger maximal response.

Compound Libraries

4BP-TQS is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 405.31
Formula C18H17BrN2O2S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 360791-49-7
PubChem ID 2857838
InChI Key YNCXHXYZTLIZTO-UHFFFAOYSA-N
Smiles BrC1=CC=C(C2NC(C=CC(S(=O)(N)=O)=C4)=C4C3C2CC=C3)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.53 100

Preparing Stock Solutions

The following data is based on the product molecular weight 405.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.47 mL 12.34 mL 24.67 mL
5 mM 0.49 mL 2.47 mL 4.93 mL
10 mM 0.25 mL 1.23 mL 2.47 mL
50 mM 0.05 mL 0.25 mL 0.49 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Gill et al (2011) Agonist activation of α7 nicotinic acetylcholine receptors via an allosteric transmembrane site. Proc.Natl.Acad.Sci.U.S.A. 108 5867 PMID: 21436053


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Keywords: alpha7 nAChR a7 agonists nicotinic α7 Nicotinic (a7) Receptors

1 Citation for 4BP-TQS

Citations are publications that use Tocris products. Selected citations for 4BP-TQS include:

Zhang et al (2015) Functional Impact of 14 Single Nucleotide Polymorphisms Causing Missense Mutations of Human α7 Nicotinic Receptor. Proc Natl Acad Sci U S A 10 e0137588 PMID: 26340537


Do you know of a great paper that uses 4BP-TQS from Tocris? If so please let us know.

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Pathways for 4BP-TQS

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